The International Society for Stem Cell Research has updated its Guidelines for Stem Cell
Research and Clinical Translation in order to address advances in stem cell science and …

The ISSCR Guidelines for Stem Cell Research and Clinical Translation were last revised in
2016. Since then, rapid progress has been made in research areas related to in vitro culture …

Diabetes mellitus (DM) is a highly prevalent condition affecting about 347 million people
worldwide. In addition to its numerous clinical implications, DM also exerts a negative effect on …

Gonadal development is a complex process that involves sex determination followed by
divergent maturation into either testes or ovaries 1 . Historically, limited tissue accessibility, a …

We recently derived mouse expanded potential stem cells (EPSCs) from individual blastomeres
by inhibiting the critical molecular pathways that predispose their differentiation. EPSCs …

Genome‐wide epigenetic reprogramming by demethylation occurs in early mouse embryos
and primordial germ cells. In early embryos many single‐copy sequences become …

Objective: To characterise sleep quality and assess degree of daytime sleepiness among
medical students of Karachi. Methods: The cross-sectional study was conducted between …

The long noncoding RNA Xist is expressed from only the paternal X chromosome in mouse
preimplantation female embryos and mediates transcriptional silencing of that chromosome. …

This study investigates how a targeted mutation of a paternally expressed imprinted gene
regulates multiple aspects of foetal and post–natal development including placental size, …

Steel factor is an essential survival and proliferation factor for primordial germ cells (PGCs)
during their migration in the early mouse embryo. PGCs arise during gastrulation, and …