Balancing selection describes any form of natural selection, which results in the persistence
of multiple variants of a trait at intermediate frequencies within populations. By offering up a …

Colorectal cancer (CRC) is the second most common cause of cancer deaths in Canadian
men and women – accounting for almost 12% of all cancer deaths. In Ontario, it is estimated …

Heliconius butterflies represent a recent radiation of species, in which wing pattern divergence
has been implicated in speciation. Several loci that control wing pattern phenotypes have …

Autism is a common neurodevelopmental disorder with a complex mode of inheritance. It is
one of the most highly heritable of the complex disorders, although the underlying genetic …

The wing patterns of butterflies and moths (Lepidoptera) are diverse and striking examples
of evolutionary diversification by natural selection 1 , 2 . Lepidopteran wing colour patterns …

Submicroscopic copy-number imbalances contribute significantly to the genetic etiology of
human disease. Here, we report a novel microduplication hot spot at Xp11.22 identified in six …

Large-scale systematic resequencing has been proposed as the key future strategy for the
discovery of rare, disease-causing sequence variants across the spectrum of human complex …

Supergenes are tight clusters of loci that facilitate the co-segregation of adaptive variation,
providing integrated control of complex adaptive phenotypes 1 . Polymorphic supergenes, in …

To understand evolutionary paths connecting diverse biological forms, we defined a three-dimensional
genotypic space separating two flower color morphs of Antirrhinum. A hybrid …

Mutations of the calcium/calmodulin-dependent serine protein kinase (CASK) gene have
recently been associated with X-linked mental retardation (XLMR) with microcephaly, optic …