Individualized medicine is the healthcare strategy that rebukes the idiomatic dogma of ‘losing
sight of the forest for the trees’. We are entering a new era of healthcare where it is no …

Transport processes in cancer are the focus of transport oncophysics (TOP). In the TOP
approach, the sequential negotiation of transport barriers is critical to both drug delivery and …

Despite decades of effort on research and drug development for cancer treatment, cancer still
remains one of the major causes of human deaths in the world [1]. Human cancers consist …

Angiogenesis, a hallmark of cancer, is induced by vascular endothelial growth factor–A (hereafter
VEGF). As a result, anti-VEGF therapy is commonly used for cancer treatment. Recent …

Nanovectors hold substantial promise in abating the off-target effects of therapeutics by
providing a means to selectively accumulate payloads at the target lesion, resulting in an …

Controlling size, shape and uniformity of porous constructs remains a major focus of the
development of porous materials. Over the past two decades, we have seen significant …

Immune profiling of tissue through multiplex immunohistochemistry is important for the
investigation of immune cell dynamics, and it can contribute to disease prognosis and evaluation …

The capillary wall is the chief barrier to tissue entry of therapeutic nanoparticles, thereby
dictating their efficacy. Collagen fibers are an important component of capillary walls, affecting …

We present a successful hierarchical modeling approach which accounts for interface
effects on diffusivity, ignored in classical continuum theories. A molecular dynamics derived …

This manuscript demonstrates a mechanically robust implantable nanofluidic membrane
capable of tunable long-term zero-order release of therapeutic agents in ranges relevant for …