One-third of all protein-coding genes from bacterial genomes cannot be annotated with a
function. Here, to investigate the functions of these genes, we present genome-wide mutant …

High similarity between yeast and human mitochondria allows functional genomic study of
Saccharomyces cerevisiae to be used to identify human genes involved in disease 1. So far, …

Haploinsufficiency is defined as a dominant phenotype in diploid organisms that are heterozygous
for a loss-of-function allele. Despite its relevance to human disease, neither the extent …

A comprehensive understanding of the cellular functions of the Hsp90 molecular chaperone
has remained elusive. Although Hsp90 is essential, highly abundant under normal …

Understanding microbial gene functions relies on the application of experimental genetics
in cultured microorganisms. However, the vast majority of bacteria and archaea remain …

XCMS Online ( xcmsonline.scripps.edu ) is a cloud-based informatic platform designed to
process and visualize mass-spectrometry-based, untargeted metabolomic data. Initially, the …

DNA methylation acts in concert with restriction enzymes to protect the integrity of prokaryotic
genomes. Studies in a limited number of organisms suggest that methylation also …

Identifying the genetic variation underlying quantitative trait loci remains problematic.
Consequently, our molecular understanding of genetically complex, quantitative traits is limited. To …

Diverse soil-resident bacteria can contribute to plant growth and health, but the molecular
mechanisms enabling them to effectively colonize their plant hosts remain poorly understood. …

We have quantitatively monitored the sporulation and germination efficiencies of ≈4,200
yeast deletion strains in parallel by using a molecular bar coding strategy. In a single study, we …