Schizophrenia (SZ) is a severe psychiatric illness that affects ∼1% of the population and has
a strong genetic underpinning. Recently, genome-wide analysis of copy-number variation (…

Crohn's disease (CD) is a complex disorder resulting from the interaction of intestinal
microbiota with the host immune system in genetically susceptible individuals. The largest meta-…

Despite extensive research, amyotrophic lateral sclerosis (ALS) remains a progressive and
invariably fatal neurodegenerative disease. Limited knowledge of the underlying causes of …

An essential component in identifying human remains is the documentation of the
decedent's visible characteristics, such as eye, hair and skin color. However, if a decedent is …

The transmission/disequilibrium test (TDT), a family-based test of linkage and association, is
a popular and intuitive statistical test for studies of complex inheritance, as it is …

Complex traits, including migraine, often aggregate in families, but the underlying genetic
architecture behind this is not well understood. The aggregation could be explained by rare, …

Sudden unexplained deaths (SUD) in apparently healthy individuals, for which the causes
of deaths remained undetermined after comprehensive forensic investigations and autopsy, …

A periurban outbreak of visceral leishmaniasis (VL) caused by the protozoan Leishmania
chagasi is ongoing outside Natal, northeast Brazil. Manifestations range from asymptomatic …

Background Several copy number variants (CNVs) have been implicated as susceptibility
factors for schizophrenia (SZ). Some of these same CNVs also increase risk for autism …

DNA mixture analysis is a current topic of discussion in the forensics literature. Of particular
interest is how to approach mixtures where allelic drop-out and/or drop-in may have occurred…