Laboratory mice, while paramount for understanding basic biological phenomena, are limited
in modeling complex diseases of humans and other free-living mammals. Because the …

Complex human traits are influenced by variation in regulatory DNA through mechanisms
that are not fully understood. Because regulatory elements are conserved between humans …

Genotyping microarrays are an important resource for genetic mapping, population genetics,
and monitoring of the genetic integrity of laboratory stocks. We have developed the third …

The Collaborative Cross (CC) is a multiparent panel of recombinant inbred (RI) mouse strains
derived from eight founder laboratory strains. RI panels are popular because of their long-…

The second-generation antipsychotic olanzapine is effective in reducing psychotic symptoms
but can cause extreme weight gain in human patients. We investigated the role of the gut …

During 1997 JET operation with DT plasmas, 35 g of tritium were introduced into the torus,
mainly by gas puffing. It was found that during this period, the torus tritium inventory would …

Pneumolysin, a member of the thiol-activated cytolysin family of toxins, is a virulence factor
from the Gram-positive bacterium Streptococcus pneumoniae. The toxin forms large …

Host genetic variation is known to contribute to differential pathogenesis following infection.
Mouse models allow direct assessment of host genetic factors responsible for susceptibility …

The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little
is known about the spatial and genetic structure of the parasite population in that country. …

Inflammatory bowel disease (IBD) is an immune-mediated condition driven by improper
responses to intestinal microflora in the context of environmental and genetic background. …