THE discussions and inferences submitted in the present volume are offered with the
diffidence and distrust which must necessarily accompany the results of investigations in a field …

Background : Hypertension (HTN) is the single greatest cardiovascular risk factor worldwide.
HTN management is usually guided by brachial cuff blood pressure (BP), but questions …

Herbaria archive a record of changes of worldwide plant biodiversity harbouring millions of
specimens that contain DNA suitable for genome sequencing. To profit from this resource, it …

The distribution of effect sizes of adaptive substitutions has been central to evolutionary
biology since the modern synthesis. Early theory proposed that because large-effect mutations …

Environmental stress is a major driver of ecological community dynamics and agricultural
productivity. This is especially true for soil water availability, because drought is the greatest …

Extensive empirical work has demonstrated local adaptation to discrete environments, yet
few studies have elucidated the genetic and environment mechanisms that generate it. Here, …

The goal of identifying the genes or even nucleotides underlying quantitative and adaptive
traits has been characterized as the ‘QTN programme’ and has recently come under severe …

Echocardiographic evidence has suggested abnormalities of the myocardial function in
patients with ankylosing spondylitis. In this work the cardiac function in patients with ankylosing …

… Indeed, the degree of allele frequency differentiation in promoter regions between the
coastal and inland ecotypes (Gould et al., 2017) was predictive of the magnitude of differential …

The early stages of speciation are often characterized by the formation of partially reproductively
isolated ecotypes, which evolve as a by‐product of divergent selective forces that are …