… Work from the Vanderhyden laboratory was funded as part of the Program on Oocyte Health
under the Strategic Initiative on Healthy Gametes and Great Embryos of the CIHR Institute of …

… -2 (as described above), we have recently found that membrane-bound KitL-2 promotes the
growth and survival of oocytes via a PI3K-mediated mechanism (Thomas and Vanderhyden, …

Ovarian cancer is the fifth most frequently occurring cancer among women and leading cause
of gynecological cancer deaths in North America. Although the etiology of ovarian cancer …

We have investigated the effects of steroids on the intracellular calcium ion concentration [Ca2+]i
in chicken granulosa cells obtained from the two largest preovulatory follicles of laying …

Although it has been shown that granulosa cells regulate the growth and meiotic maturation
of mammalian oocytes, there is little evidence of a role for the oocyte in the differentiation or …

In women, >80% of malignant ovarian tumors are of epithelial origin. Early detection of
these tumors is very challenging,and extensive ip dissemination is common by the time of …

The expansion, or mucification, of the mouse cumulus oophorus in vitro requires the
presence of an enabling factor secreted by the oocyte as well as stimulation with follicle-stimulating …

Oncolytic viruses are generally designed to be cancer selective on the basis of a single
genetic mutation. JX-594 is a thymidine kinase (TK) gene-inactivated oncolytic vaccinia virus …

Improvement of ovarian cancer patient outcome requires well-characterized animal models
in which to evaluate novel therapeutics. Xenograft models are frequently used, but with little …

Immature oocytes were collected from immature female rats (60−65 g) 40 h after injection with
6 IU pregnant mare’s serum gonadotropin (PMSG). Oocytes were matured cumulus-intact (…