Abstract Systems biology has experienced dramatic growth in the number, size, and
complexity of computational models. To reproduce simulation results and reuse models, …

Previous genome-wide association studies (GWAS), conducted by our group and others,
have identified loci that harbor risk variants for neurodegenerative diseases, including …

Background Efforts to improve the computational reconstruction of the Saccharomyces
cerevisiae biochemical reaction network and to refine the stoichiometrically constrained …

Updates to maintain a state-of-the art reconstruction of the yeast metabolic network are
essential to reflect our understanding of yeast metabolism and functional organization, to …

Modern biomedical data collection is generating exponentially more data in a multitude of
formats. This flood of complex data poses significant opportunities to discover and understand …

We have compared 12 genome-scale models of the Saccharomyces cerevisiae metabolic
network published since 2003 to evaluate progress in reconstruction of the yeast metabolic …

Background: The availability of whole-genome sequencing data in large studies has enabled
the assessment of coding and noncoding variants across the allele frequency spectrum for …

… Author links open overlay panel Benjamin D Heavner , Nathan D Price … Cassen, BD
Heavner, NE Ajami, A. Herrmann, E. Simeonidis, ND Price …

Gene regulatory and metabolic network models have been used successfully in many
organisms, but inherent differences between them make networks difficult to integrate. …

Background Genetic factors that influence kidney traits have been understudied for low
frequency and ancestry-specific variants. Methods We combined whole genome sequencing (…