User profiles for B. F. Voight

Benjamin F. Voight

Associate Professor, Dept. of Systems Pharmacology and Translational Therapeutics, Dept …
Verified email at pennmedicine.upenn.edu
Cited by 77985

[HTML][HTML] Guidelines for investigating causality of sequence variants in human disease

…, SR Sunyaev, D Valle, BF Voight… - Nature, 2014 - nature.com
The discovery of rare genetic variants is accelerating, and clear guidelines for distinguishing
disease-causing sequence variants from the many potentially functional variants present in …

Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants

…, T Kessler, C Willenborg, R Laaksonen, BF Voight… - Stroke, 2014 - Am Heart Assoc
Background and Purpose— Ischemic stroke (IS) and coronary artery disease (CAD) share
several risk factors and each has a substantial heritability. We conducted a genome-wide …

Biological, clinical and population relevance of 95 loci for blood lipids

…, NJ Wareham, G Waeber, P Vollenweider, BF Voight… - Nature, 2010 - nature.com
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …

[HTML][HTML] A map of recent positive selection in the human genome

BF Voight, S Kudaravalli, X Wen, JK Pritchard - PLoS biology, 2006 - journals.plos.org
The identification of signals of very recent positive selection provides information about the
adaptation of modern humans to local conditions. We report here on a genome-wide scan for …

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

R Saxena, BF Voight, V Lyssenko, NP Burtt… - Science, 2007 - science.org
New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight
into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (…

[HTML][HTML] Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

BF Voight, GM Peloso, M Orho-Melander… - The Lancet, 2012 - thelancet.com
Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

…, T Lajunen, N Grarup, T Sparsø, A Doney, BF Voight… - Nature …, 2010 - nature.com
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …

Hundreds of variants clustered in genomic loci and biological pathways affect human height

…, NR Robertson, V Steinthorsdottir, JP Tyrer, BF Voight… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

…, SR Bornstein, J Grässler, L Groop, BF Voight… - Nature, 2011 - nature.com
Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

E Zeggini, LJ Scott, R Saxena, BF Voight, JL Marchini… - Nature …, 2008 - nature.com
Genome-wide association (GWA) studies have identified multiple loci at which common variants
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …