User profiles for B. F. Voight
Benjamin F. VoightAssociate Professor, Dept. of Systems Pharmacology and Translational Therapeutics, Dept … Verified email at pennmedicine.upenn.edu Cited by 77985 |
[HTML][HTML] Guidelines for investigating causality of sequence variants in human disease
…, SR Sunyaev, D Valle, BF Voight… - Nature, 2014 - nature.com
The discovery of rare genetic variants is accelerating, and clear guidelines for distinguishing
disease-causing sequence variants from the many potentially functional variants present in …
disease-causing sequence variants from the many potentially functional variants present in …
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants
Background and Purpose— Ischemic stroke (IS) and coronary artery disease (CAD) share
several risk factors and each has a substantial heritability. We conducted a genome-wide …
several risk factors and each has a substantial heritability. We conducted a genome-wide …
Biological, clinical and population relevance of 95 loci for blood lipids
…, NJ Wareham, G Waeber, P Vollenweider, BF Voight… - Nature, 2010 - nature.com
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
[HTML][HTML] A map of recent positive selection in the human genome
The identification of signals of very recent positive selection provides information about the
adaptation of modern humans to local conditions. We report here on a genome-wide scan for …
adaptation of modern humans to local conditions. We report here on a genome-wide scan for …
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight
into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (…
into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (…
[HTML][HTML] Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …
traits, we performed meta-analyses of 21 genome-wide association studies informative for …
Hundreds of variants clustered in genomic loci and biological pathways affect human height
…, NR Robertson, V Steinthorsdottir, JP Tyrer, BF Voight… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
…, SR Bornstein, J Grässler, L Groop, BF Voight… - Nature, 2011 - nature.com
Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Genome-wide association (GWA) studies have identified multiple loci at which common variants
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …