… That is, without external information, it becomes unclear which particular partition, within the
enormous number of roughly equally good ones, is more scientifically meaningful 26 . And, …

The outcomes of evolution are determined by a stochastic dynamical process that governs
how mutations arise and spread through a population. However, it is difficult to observe these …

Gut microbiota are shaped by a combination of ecological and evolutionary forces. While
the ecological dynamics have been extensively studied, much less is known about how …

… Ultimately, this intuition can only be justified a posteriori by the generally good agreement
between our analytical results and computer simulations discussed below. A more thorough …

Negative selection is a ubiquitous evolutionary force, but its effects on diversity in large
samples are poorly understood. Cvijović, Good, and Desai obtain simple analytical expressions …

Natural environments are never truly constant, but the evolutionary implications of temporally
varying selection pressures remain poorly understood. Here we investigate how the fate of …

… In addition, the traditional measure of the deleterious load ceases to be a good predictor of
diversity in the interference selection regime, with more than an order of magnitude variation …

Genetic interactions can strongly influence the fitness effects of individual mutations, yet the
impact of these epistatic interactions on evolutionary dynamics remains poorly understood. …

Across diverse microbiotas, species abundances vary in time with distinctive statistical
behaviors that appear to generalize across hosts, but the origins and implications of these …

Gut microbial communities can respond to antibiotic perturbations by rapidly altering their
taxonomic and functional composition. However, little is known about the strain-level …