Objective. Spinal cord injury causes a drastic loss of motor, sensory and autonomic function.
The goal of this project was to investigate the use of intraspinal microstimulation (ISMS) for …

Aims/hypothesis A new class of treatments termed bioelectronic medicines are now emerging
that aim to target individual nerve fibres or specific brain circuits in pathological conditions …

Objective. The vision of bioelectronic medicine is to treat disease by modulating the signaling
of visceral nerves near various end organs. In small animal models, the nerves of interest …

Objective. Most preparations for making neural recordings degrade over time and eventually
fail due to insertion trauma and reactive tissue response. The magnitudes of these …

Objective. The goal of this study was to decode sensory information from the dorsal root
ganglia (DRG) in real time, and to use this information to adapt the control of unilateral stepping …

The nascent field of bioelectronic medicine seeks to decode and modulate peripheral nervous
system signals to obtain therapeutic control of targeted end organs and effectors. Current …

The biological central pattern generator (CPG) integrates open and closed loop control to
produce over-ground walking. The goal of this study was to develop a physiologically based …

The overall objective of this project is to develop a feedback-driven intraspinal microstimulation
(ISMS) system. We hypothesize that ISMS will enhance the functionality of stepping by …

… BJ Holinski is with the Biomedical Engineering Department, University of Alberta, Edmonton,
… Holinski received the BS degree in electrical engineering and the Ph.D. degree in biomed…

A proposed Locomotion Processing Unit (LPU) is described for generating stimulation patterns
for restoring walking in individuals with spinal cord injury (SCI). The LPU operates using …