All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the relocalization …

Long-range and highly accurate de novo assembly from short-read data is one of the most
pressing challenges in genomics. Recently, it has been shown that read pairs generated by …

Animal genomes show networks of deeply conserved gene linkages whose phylogenetic
scope and chromosomal context remain unclear. Here, we report chromosome-scale …

Recent advances in genomic sequencing technology and computational assembly methods
have allowed scientists to improve reference genome assemblies in terms of contiguity and …

The extinct passenger pigeon was once the most abundant bird in North America, and possibly
the world. Although theory predicts that large populations will be more genetically diverse…

DNA methylation is a key epigenetic property that drives gene regulatory programs in
development and disease. Current single-cell methods that produce high quality methylomes are …

Single-cell combinatorial indexing (sci) with transposase-based library construction increases
the throughput of single-cell genomics assays but produces sparse coverage in terms of …

All living things experience entropy, manifested as a loss of inherited genetic and epigenetic
information over time. As budding yeast cells age, epigenetic changes result in a loss of cell …

The American alligator, Alligator mississippiensis, like all crocodilians, has temperature-dependent
sex determination, in which the sex of an embryo is determined by the incubation …

Here we present advancements in single-cell combinatorial indexed Assay for Transposase
Accessible Chromatin (sciATAC) to measure chromatin accessibility that leverage nanowell …