… We thank Sean Escola, James Fitzgerald, Grigori Guitchounts, Johannes Letzkus, Philip
Tovote and the Ölveczky Lab for helpful comments on the manuscript. This work was supported …

… However, most established motor tasks, even in rats, are designed to interrogate the
function and plasticity of cortical controllers (Olveczky , 2011), making them ill suited for the …

… Rodent models also hold significant promise (Ölveczky 2011), given the feasibility of high-…
, Reza Shadmehr, and members of the Ölveczky lab for comments on the manuscript. …

… We thank all members of the Olveczky lab for feedback and advice and acknowledge special
experimental and computational assistance from Ashesh Dhawale, Steffen Wolff, Sasha …

To signal the onset of salient sensory features or execute well-timed motor sequences,
neuronal circuits must transform streams of incoming spike trains into precisely timed firing. To …

10.7554/eLife.27702.001 Addressing how neural circuits underlie behavior is routinely done
by measuring electrical activity from single neurons in experimental sessions. While such …

Executing a motor skill requires the brain to control which muscles to activate at what times.
How these aspects of control—motor implementation and timing—are acquired, and whether …

Addressing the neural mechanisms underlying complex learned behaviors requires training
animals in well-controlled tasks, an often time-consuming and labor-intensive process that …

Though the temporal precision of neural computation has been studied intensively, a data-driven
determination of this precision remains a fundamental challenge. Reproducible spike …

Trial-to-trial movement variability can both drive motor learning and interfere with expert
performance, suggesting benefits of regulating it in context-specific ways. Here we address …