No Pasaran! Role of the axon initial segment in the regulation of protein transport and the maintenance of axonal identity

C Leterrier, B Dargent - Seminars in cell & developmental biology, 2014 - Elsevier
… 2B). This filter is established at the same time as the AIS (between 3 and 5 days in culture),
and depends on AIS integrity, as shown by its disappearance after ankG depletion [14]. …

A targeting motif involved in sodium channel clustering at the axonal initial segment

…, A Moussif, MP Fache, D Debanne, B Dargent - Science, 2003 - science.org
The sorting of sodium channels to axons and the formation of clusters are of primary
importance for neuronal electrogenesis. Here, we showed that the cytoplasmic loop connecting …

Voltage-gated sodium channel organization in neurons: protein interactions and trafficking pathways

C Leterrier, A Brachet, MP Fache, B Dargent - Neuroscience letters, 2010 - Elsevier
… ankG is segregated at the AIS, whereas the other neuronal ankyrin, ankyrin B, is located
along the distal axon in cultured hippocampal neurons and in myelinated fibers [3]. These …

[PDF][PDF] Nanoscale architecture of the axon initial segment reveals an organized and robust scaffold

…, J Potier, G Caillol, C Debarnot, FR Boroni, B Dargent - Cell reports, 2015 - cell.com
… (B) Intensity profiles for each channel along the yellow line. (C and D) Same as (A) and (B)
for an AIS from a sister culture treated with latrunculin A (latA; 5 mM; 1 hr). (E) Radial distance …

A dynamic formin-dependent deep F-actin network in axons

…, Y Tang, L Wang, K Ladt, J Loi, B Dargent… - Journal of Cell …, 2015 - rupress.org
… 1 B (corresponding events in still frames and kymograph are labeled by similar arrowheads
in Fig. 1, A and B). Note that actin trail kinetics appear as “fluorescent plumes” in the …

Protein kinase CK2 contributes to the organization of sodium channels in axonal membranes by regulating their interactions with ankyrin G

…, M Irondelle, S Pereira, C Leterrier, B Dargent - The Journal of cell …, 2008 - rupress.org
… Besides, CK2 phosphorylation was equally effective for interactions with the MBD of ankyrin
B and G. In addition, it was profoundly altered upon mutation of two to three serine residues. …

End-binding proteins EB3 and EB1 link microtubules to ankyrin G in the axon initial segment

…, F Castets, A Autillo-Touati, B Dargent - Proceedings of the …, 2011 - National Acad Sciences
… (B) Time course of the percentage of cells that exhibit EB3 concentrated in the AIS during
neuronal maturation. Bars indicate mean ± SEM; n = 307–620 neurons from three to five …

[HTML][HTML] Identification of an axonal determinant in the C‐terminus of the sodium channel Nav1. 2

…, E Pasqualini, MP Fache, F Jullien, B Dargent - The EMBO …, 2001 - embopress.org
… was uniformly distributed on dendrites and axons (B.Sampo, JABoudier, E.Carlier, F.… Le
Bivic, RAMaue and B.Dargent, submitted) eliminated the possibility that the sodium channel β2 …

Dynamic compartmentalization of the voltage‐gated sodium channels in axons

…, A Moussif, MP Fache, P Giraud, B Dargent - Biology of the …, 2003 - Wiley Online Library
One of the major physiological roles of the neuronal voltage‐gated sodium channel is to
generate action potentials at the axon hillock/initial segment and to ensure propagation along …

Ankyrin G restricts ion channel diffusion at the axonal initial segment before the establishment of the diffusion barrier

…, V Racine, JB Sibarita, D Choquet, B Dargent - Journal of Cell …, 2010 - rupress.org
… 1 B). This allowed us to analyze the effect of ankG on Kv-Nav … 6 B): the DIDC and the
cumulative frequency of diffusion … 6, B and C): we did not find any significant differences in the …