PA28γ is a nuclear activator of the 20S proteasome involved in the regulation of several
essential cellular processes, such as cell proliferation, apoptosis, nuclear dynamics, and cellular …

Le protéasome est responsable de la dégradation régulée d'une majeure partie des protéines
intracellulaires. Cette machinerie multimoléculaire est composée d'un cœur catalytique, le …

Precursor mRNA (pre-mRNA) splicing is an essential process for gene expression in
eukaryotes catalyzed by the spliceosome in two transesterification steps. The spliceosome is a …

The nuclear PA28γ is known to activate the 20S proteasome, but its precise cellular functions
remains unclear. Here, we identify PA28γ as a key factor that structures heterochromatin. …

PA28γ (also known as PSME3), a nuclear activator of the 20S proteasome, is involved in the
degradation of several proteins regulating cell growth and proliferation and in the dynamics …

A growing body of evidence convincingly indicates that proteasomes are not located exclusively
within cells but also in different extracellular compartments. In humans, in fact, this large …

Pre-mRNA splicing involves two sequential reactions: branching and exon ligation. The C
complex after branching undergoes remodeling to become the C ∗ complex, which executes …

… Importantly, Psme3-N151Y overexpression for 2 days did not induce ESC differentiation (Figure
S2B), demonstrating that the interactome we observed faithfully represent the one in …

A major challenge in chemotherapy is chemotherapy resistance in cells lacking p53. Here
we demonstrate that NIP30, an inhibitor of the oncogenic REGγ-proteasome, attenuates …

… Finally, we have shown that increased amount and activities of μ-calpain in leukemic B cells
(in chronic B cell leukemia and acute lymphoblastic leukemia ALL respectively) is a direct …