INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

We have previously linked families with autosomal-dominant, late-onset parkinsonism to
chromosome 12p11.2-q13.1 (PARK8). By high-resolution recombination mapping and …

The stress hormone–regulating hypothalamic-pituitary-adrenal (HPA) axis has been
implicated in the causality 1 as well as the treatment of depression 2 . To investigate a possible …

Background Restless legs syndrome is a prevalent chronic neurological disorder with
potentially severe mental and physical health consequences. Clearer understanding of the …

The dystonias are a common clinically and genetically heterogeneous group of movement
disorders. More than ten loci for inherited forms of dystonia have been mapped, but only three …

High-throughput DNA sequencing (HTS) is of increasing importance in the life sciences. One
of its most prominent applications is the sequencing of whole genomes or targeted regions …

Migraine is a debilitating neurological disorder affecting around one in seven people worldwide,
but its molecular mechanisms remain poorly understood. There is some debate about …

The P2RX7 gene is located within a region on chromosome 12q24.31 that has been identified
as a susceptibility locus for affective disorders by linkage and association studies. P2RX7 …

Major depression (MD) is one of the most prevalent psychiatric disorders and a leading
cause of loss in work productivity. A combination of genetic and environmental risk factors …

Migraine is the most common brain disorder, affecting approximately 14% of the adult
population, but its molecular mechanisms are poorly understood. We report the results of a meta-…