… The light chains of BoNT/A, /B and /F and TeNT bind one Zn atom [12], [… Poulain, unpublished
observation), antagonize the inhibitory action of intracellularly applied TeNT or BoNT/A, /B. …

… The carboxy-terminal part of A2 extends through the central pore of the B pentamer and is
linked non-covalently to the B subunits. Heat labile enterotoxin (HLT) from Escherichia coli is …

… Here we show that tetanus and botulinum toxins serotype B are zinc endopeptidases, the …
To identify the target and site of action of TeTx and BoNT/B, we electroeluted and sequenced …

Tetanus and botulinum neurotoxins are the most potent toxins known. They bind to nerve
cells, penetrate the cytosol and block neurotransmitter release. Comparison of their predicted …

… to BoNT/B and shares with it the same cleavage site in its SNARE target [67]. Similar to the
bont B gene, the tent gene is also located on a large-sized plasmid, and BoNT/B shares the …

… (B) Immunofluorescent confocal micrographs of cultured cerebellar granule cells double-labeled
with anti-PLD1 Abs (red) and anti-SNAP-25 or anti-synaptophysin Abs (green). (Bar = 5 …

… Highly purified preparations of the light chain of tetanus and botulinum B and F neurotoxins
cleaved specifically VAMP/synaptobrevin, an integral membrane protein of small synaptic …

… (B) Transgene expression monitored by YFP fluorescence in cerebellar sections (Upper Left);
(Lower Left) calbindin immunolabeling; (Upper Right) GABA immunolabeling; (Lower Right…

… Because presynaptic cortico–LA LTP becomes independent of thalamic afferent activity,
and NMDA receptor activation, if it is induced in the presence of a GABA B receptor antagonist (…

… Reference to this paper should be made as follows: Poulain, B., Popoff, MR and Molgó, J.
(2008) ‘How do the Botulinum Neurotoxins block neurotransmitter release: from botulism to the …