User profiles for B. Umans

Ben Umans

University of Chicago
Verified email at uchicago.edu
Cited by 1751

Where are the disease-associated eQTLs?

BD Umans, A Battle, Y Gilad - Trends in Genetics, 2021 - cell.com
… (B) Correlating genotypes with expression levels in healthy subjects can reveal the targets
… Here, mutations from (A) correlate with expression changes in gene B but not gene A, …

[PDF][PDF] Sensory neurons that detect stretch and nutrients in the digestive system

EK Williams, RB Chang, DE Strochlic, BD Umans… - Cell, 2016 - cell.com
Neural inputs from internal organs are essential for normal autonomic function. The vagus
nerve is a key body-brain connection that monitors the digestive, cardiovascular, and …

Neural sensing of organ volume

BD Umans, SD Liberles - Trends in neurosciences, 2018 - cell.com
UmansUmans … (B) Whole vagus nerve electrophysiological responses to airway
stretch are lost in Piezo2epKO mice. WT, wild type. Adapted from …

[HTML][HTML] Vagal sensory neuron subtypes that differentially control breathing

RB Chang, DE Strochlic, EK Williams, BD Umans… - Cell, 2015 - cell.com
Breathing is essential for survival and under precise neural control. The vagus nerve is a
major conduit between lung and brain required for normal respiration. Here, we identify two …

[HTML][HTML] Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

P Baral, BD Umans, L Li, A Wallrapp, M Bist… - Nature medicine, 2018 - nature.com
… We next purified CD4 + T cells, B cells, neutrophils, and γδ T cells from mouse lungs, and
performed quantitative PCR analysis for Trpv1 compared with that in sensory ganglia. …

[PDF][PDF] An airway protection program revealed by sweeping genetic control of vagal afferents

SL Prescott, BD Umans, EK Williams, RD Brust… - Cell, 2020 - cell.com
… To monitor airway defense reflexes, we developed an in vivo preparation in anesthetized
mice to record swallowing responses to laryngeal stimuli (Figure 1B). Solutions were intro…

Fatty acids linked to cardiovascular mortality are associated with risk factors

…, WS Harris, J Kennish, BD Umans… - … journal of circumpolar …, 2015 - Taylor & Francis
Background Although saturated fatty acids (FAs) have been linked to cardiovascular
mortality, it is not clear whether this outcome is attributable solely to their effects on low-density …

Genetic determinants of penicillin tolerance in Vibrio cholerae

AI Weaver, SG Murphy, BD Umans… - Antimicrobial Agents …, 2018 - Am Soc Microbiol
… TG and TP reactions are mediated by two spatiotemporally distinct entities, the Rod system
(with RodA as the polymerase and a class B penicillin binding protein [bPBP] as the cross-…

[HTML][HTML] Regions of very low H3K27me3 partition the Drosophila genome into topological domains

S El-Sharnouby, B Fischer, JP Magbanua, B Umans… - PLoS …, 2017 - journals.plos.org
… (B) Histogram showing the distribution of distances from the borders of the 61 bands used
in (A) to the nearest D/E boundary. (C) Examples of mapped polytene band locations showing …

A transposon screen identifies genetic determinants of Vibrio cholerae resistance to high-molecular-weight antibiotics

T Dörr, F Delgado, BD Umans… - Antimicrobial agents …, 2016 - Am Soc Microbiol
… (A and B) Volcano plots depicting the ratio of read counts mapped to individual genes in
transposon libraries plated onto vancomycin (200 μg/ml) (A) or bacitracin (200 μg/ml) (B) …