User profiles for B. Umans
Ben UmansUniversity of Chicago Verified email at uchicago.edu Cited by 1751 |
Where are the disease-associated eQTLs?
… (B) Correlating genotypes with expression levels in healthy subjects can reveal the targets
… Here, mutations from (A) correlate with expression changes in gene B but not gene A, …
… Here, mutations from (A) correlate with expression changes in gene B but not gene A, …
[PDF][PDF] Sensory neurons that detect stretch and nutrients in the digestive system
Neural inputs from internal organs are essential for normal autonomic function. The vagus
nerve is a key body-brain connection that monitors the digestive, cardiovascular, and …
nerve is a key body-brain connection that monitors the digestive, cardiovascular, and …
Neural sensing of organ volume
BD Umans, SD Liberles - Trends in neurosciences, 2018 - cell.com
… Umans … Umans … (B) Whole vagus nerve electrophysiological responses to airway
stretch are lost in Piezo2epKO mice. WT, wild type. Adapted from …
stretch are lost in Piezo2epKO mice. WT, wild type. Adapted from …
[HTML][HTML] Vagal sensory neuron subtypes that differentially control breathing
Breathing is essential for survival and under precise neural control. The vagus nerve is a
major conduit between lung and brain required for normal respiration. Here, we identify two …
major conduit between lung and brain required for normal respiration. Here, we identify two …
[HTML][HTML] Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia
… We next purified CD4 + T cells, B cells, neutrophils, and γδ T cells from mouse lungs, and
performed quantitative PCR analysis for Trpv1 compared with that in sensory ganglia. …
performed quantitative PCR analysis for Trpv1 compared with that in sensory ganglia. …
[PDF][PDF] An airway protection program revealed by sweeping genetic control of vagal afferents
SL Prescott, BD Umans, EK Williams, RD Brust… - Cell, 2020 - cell.com
… To monitor airway defense reflexes, we developed an in vivo preparation in anesthetized
mice to record swallowing responses to laryngeal stimuli (Figure 1B). Solutions were intro…
mice to record swallowing responses to laryngeal stimuli (Figure 1B). Solutions were intro…
Fatty acids linked to cardiovascular mortality are associated with risk factors
…, WS Harris, J Kennish, BD Umans… - … journal of circumpolar …, 2015 - Taylor & Francis
Background Although saturated fatty acids (FAs) have been linked to cardiovascular
mortality, it is not clear whether this outcome is attributable solely to their effects on low-density …
mortality, it is not clear whether this outcome is attributable solely to their effects on low-density …
Genetic determinants of penicillin tolerance in Vibrio cholerae
… TG and TP reactions are mediated by two spatiotemporally distinct entities, the Rod system
(with RodA as the polymerase and a class B penicillin binding protein [bPBP] as the cross-…
(with RodA as the polymerase and a class B penicillin binding protein [bPBP] as the cross-…
[HTML][HTML] Regions of very low H3K27me3 partition the Drosophila genome into topological domains
S El-Sharnouby, B Fischer, JP Magbanua, B Umans… - PLoS …, 2017 - journals.plos.org
… (B) Histogram showing the distribution of distances from the borders of the 61 bands used
in (A) to the nearest D/E boundary. (C) Examples of mapped polytene band locations showing …
in (A) to the nearest D/E boundary. (C) Examples of mapped polytene band locations showing …
A transposon screen identifies genetic determinants of Vibrio cholerae resistance to high-molecular-weight antibiotics
… (A and B) Volcano plots depicting the ratio of read counts mapped to individual genes in
transposon libraries plated onto vancomycin (200 μg/ml) (A) or bacitracin (200 μg/ml) (B) …
transposon libraries plated onto vancomycin (200 μg/ml) (A) or bacitracin (200 μg/ml) (B) …