User profiles for C. A. Darby

Charlotte A Darby

Takeda Pharmaceuticals
Verified email at jhu.edu
Cited by 7285

Piercing the dark matter: bioinformatics of long-range sequencing and mapping

FJ Sedlazeck, H Lee, CA Darby, MC Schatz - Nature Reviews Genetics, 2018 - nature.com
Several new genomics technologies have become available that offer long-read sequencing
or long-range mapping with higher throughput and higher resolution analysis than ever …

Recruitment experience in clinical trials: literature summary and annotated bibliography

DB Hunninghake, CA Darby, JL Probstfield - Controlled clinical trials, 1987 - Elsevier
A literature review was conducted to determine what problems exist in accruing adequate
numbers of patients for clinical trials. Accrual rates are often not clearly reported, and most …

Design and characterization of a computationally optimized broadly reactive hemagglutinin vaccine for H1N1 influenza viruses

DM Carter, CA Darby, BC Lefoley, CJ Crevar… - Journal of …, 2016 - Am Soc Microbiol
CA/09 VLPs had fewer and more irregular surface glycoproteins (Fig. 3D). All wild-type
and COBRA VLPs were designed to express a mismatched NA from the N3 subtype (taxonomy …

Elicitation of protective antibodies against a broad panel of H1N1 viruses in ferrets preimmune to historical H1N1 influenza viruses

DM Carter, CA Darby, SK Johnson, MA Carlock… - Journal of …, 2017 - Am Soc Microbiol
… An ELISA utilizing a chimeric HA protein (cH6/1) was used to assess antibody reactivity
against the conserved stem region of A/California/07/09 (CA/09). In brief, Immulon 4HBX plates (…

Xenolog classification

CA Darby, M Stolzer, PJ Ropp, D Barker… - …, 2017 - academic.oup.com
Motivation Orthology analysis is a fundamental tool in comparative genomics. Sophisticated
methods have been developed to distinguish between orthologs and paralogs and to …

[HTML][HTML] LRSim: a linked-reads simulator generating insights for better genome partitioning

R Luo, FJ Sedlazeck, CA Darby, SM Kelly… - Computational and …, 2017 - Elsevier
Linked-read sequencing, using highly-multiplexed genome partitioning and barcoding, can
span hundreds of kilobases to improve de novo assembly, haplotype phasing, and other …

Vargas: heuristic-free alignment for assessing linear and graph read aligners

CA Darby, R Gaddipati, MC Schatz… - Bioinformatics, 2020 - academic.oup.com
Motivation Read alignment is central to many aspects of modern genomics. Most aligners
use heuristics to accelerate processing, but these heuristics can fail to find the optimal …

scHLAcount: allele-specific HLA expression from single-cell gene expression data

CA Darby, MJT Stubbington, PJ Marks… - …, 2020 - academic.oup.com
Bulk RNA sequencing studies have demonstrated that human leukocyte antigen (HLA)
genes may be expressed in a cell type-specific and allele-specific fashion. Single-cell gene …

Analysis of the Chunked Reading Test and reading comprehension

RP Carver, CA Darby Jr - Journal of Reading Behavior, 1972 - journals.sagepub.com
The newly developed Chunked Reading Test was further analyzed by correlating the
scores on this test with three other standardized reading tests—Davis Reading Test, Nelson-Denny …

DEVELOPMENT AND EVALUATION OF A TEST OF INFORMATION STORAGE DURING READING1

RP Carver, CA Darby Jr - Journal of Educational Measurement, 1971 - Wiley Online Library
Previous research has suggested potential advantages for a new type of item for measuring
comprehension in reading and listening. The test items are called “chunked” and consist of …