The worm has turned–microbial virulence modeled in Caenorhabditis elegans
The nematode Caenorhabditis elegans is emerging as a facile and economical model host
for the study of evolutionarily conserved mechanisms of microbial pathogenesis and innate …
for the study of evolutionarily conserved mechanisms of microbial pathogenesis and innate …
Pyogenic liver abscesses
Bacterial or pyogenic liver abscess does not represent a specific liver disease, but rather a
final common pathway of many pathologic processes. In the preantibiotic era, liver abscesses …
final common pathway of many pathologic processes. In the preantibiotic era, liver abscesses …
Quorum sensing: bacteria talk sense
CD Sifri - Clinical infectious diseases, 2008 - academic.oup.com
Cell communication in bacteria occurs through a vernacular of small diffusible chemical
signals that impact gene regulation during times of high cell density. This form of intercellular …
signals that impact gene regulation during times of high cell density. This form of intercellular …
Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens
Our laboratories have studied the mechanisms of aging (1, 2) and immune function (3) in
Caenorhabditis elegans. Herein we show that the mechanisms that govern these two …
Caenorhabditis elegans. Herein we show that the mechanisms that govern these two …
A simple model host for identifying Gram-positive virulence factors
We demonstrate the use of the nematode Caenorhabditis elegans as a facile and inexpensive
model host for several Gram-positive human bacterial pathogens. Enterococcus faecalis, …
model host for several Gram-positive human bacterial pathogens. Enterococcus faecalis, …
Transfection of Plasmodium falciparum within human red blood cells.
Plasmodium falciparum malaria parasites within human red blood cells (RBCs) have been
successfully transfected to produce chloramphenicol acetyltransferase (CAT). Electroporation …
successfully transfected to produce chloramphenicol acetyltransferase (CAT). Electroporation …
Caenorhabditis elegans as a Model Host for Staphylococcus aureus Pathogenesis
Staphylococcus aureus, an important pathogen of humans and other warm-blooded animals,
is also capable of killing the nematode Caenorhabditis elegans. Here, we show that C. …
is also capable of killing the nematode Caenorhabditis elegans. Here, we show that C. …
A pathway for phagosome maturation during engulfment of apoptotic cells
…, L Stergiou, A Tosello-Trampont, CD Sifri… - Nature cell …, 2008 - nature.com
Removal of apoptotic cells is critical for the physiological well-being of the organism 1 and
defects in corpse removal have been linked to disease states 2 , 3 . Genes regulating corpse …
defects in corpse removal have been linked to disease states 2 , 3 . Genes regulating corpse …
Risk of breakthrough SARS-CoV-2 infections in adult transplant recipients
All authors participated in conception or design of the work or the acquisition, analysis, or
interpretation of data for the work; drafting the work or revising it critically for important …
interpretation of data for the work; drafting the work or revising it critically for important …
Nested Russian Doll-Like Genetic Mobility Drives Rapid Dissemination of the Carbapenem Resistance Gene blaKPC
…, CD Sifri… - Antimicrobial agents …, 2016 - Am Soc Microbiol
The recent widespread emergence of carbapenem resistance in Enterobacteriaceae is a
major public health concern, as carbapenems are a therapy of last resort against this family of …
major public health concern, as carbapenems are a therapy of last resort against this family of …