We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n
= 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to …

Genome-wide association studies (GWASs) have focused primarily on populations of
European descent, but it is essential that diverse populations become better represented. …

Genetic association results are often interpreted with the assumption that study participation
does not affect downstream analyses. Understanding the genetic basis of participation bias …

The genetic etiology of autism spectrum disorder (ASD) is multifactorial, but how combinations
of genetic factors determine risk is unclear. In a large family sample, we show that genetic …

Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are
highly heritable neurodevelopmental conditions, with considerable overlap in their genetic …

Imaging genetics and genomics research has begun to provide insight into the molecular
and genetic architecture of neural phenotypes and the neural mechanisms through which …

Opioid dependence, a severe addictive disorder and major societal problem, has been
demonstrated to be moderately heritable. We conducted a genome-wide association study in …

Despite evidence of substantial comorbidity between psychiatric disorders and substance
involvement, the extent to which common genetic factors contribute to their co-occurrence …

Depression risk is exacerbated by genetic factors and stress exposure; however, the biological
mechanisms through which these factors interact to confer depression risk are poorly …

Genome-wide association studies (GWAS) are not fully comprehensive, as current strategies
typically test only the additive model, exclude the X chromosome, and use only one …