We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD)
involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 …

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder characterized pathologically
by ubiquitinated TAR DNA binding protein (TDP-43) inclusions. The function of TDP-43 …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is familial in 10%
of cases. We have identified a missense mutation in the gene encoding fused in sarcoma (…

We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …

Algorithms designed to identify canonical yeast prions predict that around 250 human
proteins, including several RNA-binding proteins associated with neurodegenerative disease, …

TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies in
frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The mRNA …

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective
treatment. We report the results of a moderate-scale sequencing study aimed at increasing the …

Microglial activation is implicated in the pathogenesis of ALS and can be detected in animal
models of the disease that demonstrate increased survival when treated with anti-…

The RNA-binding protein TDP-43 regulates RNA metabolism at multiple levels, including
transcription, RNA splicing, and mRNA stability. TDP-43 is a major component of the …

To elucidate the genetic architecture of amyotrophic lateral sclerosis (ALS) and find
associated loci, we assembled a custom imputation reference panel from whole-genome-sequenced …