Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
Identification of common genetic risk variants for autism spectrum disorder
…, S Djurovic, AL Dumont, JI Goldstein, CS Hansen… - Nature …, 2019 - nature.com
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
…, E Sigurdsson, T Silagadze, CS Hansen… - Nature …, 2018 - nature.com
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
[PDF][PDF] Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
[HTML][HTML] The iPSYCH2012 case–cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders
The Integrative Psychiatric Research (iPSYCH) consortium has established a large Danish
population-based Case–Cohort sample (iPSYCH2012) aimed at unravelling the genetic and …
population-based Case–Cohort sample (iPSYCH2012) aimed at unravelling the genetic and …
The genetic architecture of depression in individuals of East Asian ancestry: a genome-wide association study
Importance Most previous genome-wide association studies (GWAS) of depression have used
data from individuals of European descent. This limits the understanding of the underlying …
data from individuals of European descent. This limits the understanding of the underlying …
Strengthening of old metallic structures in fatigue with prestressed and non-prestressed CFRP laminates
B Täljsten, CS Hansen, JW Schmidt - Construction and Building Materials, 2009 - Elsevier
Test results and theoretical considerations on four different configurations of strengthened
old steel plates with a centre notch loaded in fatigue are presented in this paper. The main …
old steel plates with a centre notch loaded in fatigue are presented in this paper. The main …
[HTML][HTML] An epigenetic clock for gestational age at birth based on blood methylation data
Background Gestational age is often used as a proxy for developmental maturity by clinicians
and researchers alike. DNA methylation has previously been shown to be associated with …
and researchers alike. DNA methylation has previously been shown to be associated with …
Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective …
Background Microalbuminuria is an early sign of kidney disease in people with diabetes and
indicates increased risk of cardiovascular disease. We tested whether a urinary proteomic …
indicates increased risk of cardiovascular disease. We tested whether a urinary proteomic …