Anatomical and molecular abnormalities of excitatory neurons in the dorsolateral prefrontal
cortex (DLPFC) are found in schizophrenia. We hypothesized that brain-derived neurotrophic …

Background The profile of cortical neuroanatomical abnormalities in schizophrenia is not
fully understood, despite hundreds of published structural brain imaging studies. This study …

Upregulation of the immune response may be involved in the pathogenesis of schizophrenia
with changes occurring in both peripheral blood and brain tissue. To date, microarray …

Brain-derived neurotrophic factor (BDNF) regulates the survival and growth of neurons, and
influences synaptic efficiency and plasticity. Several studies report reduced peripheral (blood…

Glucocorticoid receptors (GR) mediate the direct effects of glucocorticoids released in response
to stress and the regulation of the hypothalamic-pituitary-adrenocortical (HPA) system …

Catechol O-methyltransferase (COMT) is involved in the inactivation of catecholamines,
including the neurotransmitter dopamine. A Val 108/158 Met functional polymorphism of the …

Genetic variation in neuregulin 1 (NRG1) is associated with schizophrenia. The disease-associated
SNPs are noncoding, and their functional implications remain unknown. We …

In development, timing is of the utmost importance, and the timing of developmental processes
often changes as organisms evolve. In human evolution, developmental retardation, or …

Context The schizophrenia-susceptibility gene dysbindin (DTNBP1on 6p22.3) encodes a
neuronal protein that binds to β-dystrobrevin and may be part of the dystrophin protein complex…

Objective: The onset of schizophrenia symptoms in late adolescence implies a neurodevelopmental
trajectory for the disease. Indeed, the γ-aminobutyric acid (GABA) inhibitory system …