PIF1 family helicases are conserved from bacteria to man. With the exception of the well-studied
yeast PIF1 helicases (eg, ScPif1 and ScRrm3), however, very little is known about how …

In Saccharomyces cerevisiae, the Pif1 helicase functions in both nuclear and mitochondrial
DNA replication and repair processes, preferentially unwinding RNA:DNA hybrids and …

Pif1 family helicases represent a highly conserved class of enzymes involved in multiple
aspects of genome maintenance. Many Pif1 helicases are multi-domain proteins, but the …

PIF1 family helicases are evolutionarily conserved among prokaryotes and eukaryotes.
These enzymes function to support genome integrity by participating in multiple DNA …

Many chemical reactions in the cell are thermodynamically unfavorable. To overcome this
barrier, the energy released from the hydrolysis of adenosine triphosphate (ATP) is coupled to …

… of Pif1 and Pif1ΔN in vivo), and we have extended these analyses to chemogenomics to
determine the effects of DNA damaging compounds during Pif1 over-expression (Sausen and …

Efficient replication and repair of the genome requires a multitude of protein–DNA
transactions. These interactions can result in a variety of consequences for DNA such as the …

In S. cerevisiae, the Pif1 helicase functions to impact both nuclear and mitochondrial DNA
replication and repair processes. Pif1 is a 5’-3’ helicase, which preferentially unwinds RNA-…

Petite integration frequency 1 (Pif1) is a 5′‐3′ helicase which plays a significant role in
maintaining the fidelity of nuclear and mitochondrial DNA. Pif1 preferentially unwinds RNA‐…

DNA helicases can unwind DNA and are required for many of the transactions that occur
during DNA replication, recombination, and repair. The PIF1 family DNA helicases are …