Promoter-proximal pausing by initiated RNA polymerase II (Pol II) and regulated release of
paused polymerase into productive elongation has emerged as a major mechanism of …

The ability to evolve is a fundamental feature of biological systems, but the mechanisms
underlying this capacity and the evolutionary dynamics of conserved core processes remain …

Aneuploidy—the state of having uneven numbers of chromosomes—is a hallmark of cancer
1 and a feature identified in yeast from diverse habitats 2 , 3 , 4 , 5 . Recent studies have …

10.7554/eLife.02238.001 Planarian flatworms regenerate every organ after amputation. Adult
pluripotent stem cells drive this ability, but how injury activates and directs stem cells into …

Deafness caused by the terminal loss of inner ear hair cells is one of the most common
sensory diseases. However, nonmammalian animals (eg, birds, amphibians, and fish) …

Aneuploid genomes, characterized by unbalanced chromosome stoichiometry (karyotype),
are associated with cancer malignancy and drug resistance of pathogenic fungi. The …

Spatial control of gene expression, at the level of both transcription and translation, is critical
for cellular differentiation [1–4]. In budding yeast, the conserved Ndr/warts kinase Cbk1 …

10.7554/eLife.10501.001 Neoblasts are an abundant, heterogeneous population of adult
stem cells (ASCs) that facilitate the maintenance of planarian tissues and organs, providing a …

10.7554/eLife.16793.001 The interrelationship between endogenous microbiota, the
immune system, and tissue regeneration is an area of intense research due to its potential …

A large population of proliferative stem cells (neoblasts) is required for physiological tissue
homeostasis and post-injury regeneration in planarians. Recent studies indicate that survival …