[HTML][HTML] The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
…, J Krishnamoorthy, V van Hoef, C Darini… - Nature …, 2021 - nature.com
The integrated stress response (ISR) is an essential stress-support pathway increasingly
recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in lung …
recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in lung …
[HTML][HTML] An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy
C Darini, N Ghaddar, C Chabot, G Assaker… - Nature …, 2019 - nature.com
… factor ATF4 to be a key mediator of tumor suppression by the PKR/eIF2α-P arm via the
upregulation of the cyclin dependent kinase (CDK) inhibitor P21 Cip1 and activation of the c-Jun-…
upregulation of the cyclin dependent kinase (CDK) inhibitor P21 Cip1 and activation of the c-Jun-…
[HTML][HTML] Breast cancer mammospheres secrete Adrenomedullin to induce lipolysis and browning of adjacent adipocytes
M Paré, CY Darini, X Yao, B Chignon-Sicard, S Rekima… - BMC cancer, 2020 - Springer
… b, and insets c & d UCP1 expression in patient breast tumor sections was detected using
immunohistochemical labeling with anti-UCP1 antibody (arrows). The immunostains are shown …
immunohistochemical labeling with anti-UCP1 antibody (arrows). The immunostains are shown …
Prevalence and characterization of Enterococcus spp. isolated from Brazilian foods
BC Gomes, CT Esteves, ICV Palazzo, ALC Darini… - Food …, 2008 - Elsevier
Enterococci can be used in the food industry as starter or probiotic cultures. However,
enterococci are also implicated in severe multi-resistant nosocomial infections. In this study, the …
enterococci are also implicated in severe multi-resistant nosocomial infections. In this study, the …
Lopinavir co-induces insulin resistance and ER stress in human adipocytes
…, MD Drici, C Darini, P Saint-Marc, C Dani… - Biochemical and …, 2009 - Elsevier
… Gene expression was quantified using the comparative C t method. … (C) Cell lysates were
analysed by Western blots using anti-IRS1 phosphoserine 312. (D) LPV decreased insulin-…
analysed by Western blots using anti-IRS1 phosphoserine 312. (D) LPV decreased insulin-…
Dissemination of blaKPC-2 by the Spread of Klebsiella pneumoniae Clonal Complex 258 Clones (ST258, ST11, ST437) and Plasmids (IncFII, IncN, IncL/M) among …
This article reports the spread of bla KPC-2 in the Sao Paulo and Rio de Janeiro states,
facilitated by globally spread K. pneumoniae clonal complex 258 (CC258) clones (ST258, ST11, …
facilitated by globally spread K. pneumoniae clonal complex 258 (CC258) clones (ST258, ST11, …
STAT1 Promotes KRAS Colon Tumor Growth and Susceptibility to Pharmacological Inhibition of Translation Initiation Factor eIF4A
S Wang, C Darini, L Désaubry, AE Koromilas - Molecular cancer therapeutics, 2016 - AACR
… that STAT1 C/C cells exhibited substantially decreased rates of tumor growth compared
with STAT1-proficient cells (Fig. 5B). Identical results were obtained when STAT1 C/C and …
with STAT1-proficient cells (Fig. 5B). Identical results were obtained when STAT1 C/C and …
Self-renewal gene tracking to identify tumour-initiating cells associated with metastatic potential
CY Darini, DF Pisani, P Hofman, F Pedeutour, I Sudaka… - Oncogene, 2012 - nature.com
Tumour-initiating cells (TICs) are rare cancer cells isolated from tumours of different origins
including high-grade tumours that sustain neoplasic progression and development of …
including high-grade tumours that sustain neoplasic progression and development of …
Plasmid-mediated quinolone resistance determinants among enterobacterial isolates from outpatients in Brazil
Objectives The aim of this study was to determine the spread of plasmid-mediated quinolone
resistance determinants [qnr-like, aac(6′)-Ib-cr and qepA genes] among nalidixic acid-…
resistance determinants [qnr-like, aac(6′)-Ib-cr and qepA genes] among nalidixic acid-…
Expansion and evolution of a virulent, extensively drug-resistant (polymyxin B-resistant), QnrS1-, CTX-M-2-, and KPC-2-producing Klebsiella pneumoniae ST11 …
…, R Martinez, ALC Darini - Journal of clinical …, 2014 - Am Soc Microbiol
In this study, we report the early expansion, evolution, and characterization of a multiresistant
Klebsiella pneumoniae clone that was isolated with increasing frequency from inpatients in …
Klebsiella pneumoniae clone that was isolated with increasing frequency from inpatients in …