Microtubules are dynamic filamentous cytoskeletal proteins composed of tubulin and are an
important therapeutic target in tumour cells. Agents that bind to microtubules have been part …

… c | The second-generation ADC brentuximab vedotin is a conjugate of a chimeric IgG1
mAb specific for CD30 and 4 monomethyl auristatin E (MMAE) moieties per IgG, which are …

… New interferon-free regimens to cure hepatitis C virus infection are likely to contain a potent
and pan-genotypic active nucleoside or nucleotide analogue. Two of these — sofosbuvir …

Background High-dose chemotherapy with autologous stem-cell transplantation is a standard
treatment for young patients with multiple myeloma. Residual disease is almost always …

Acquired genomic aberrations have been shown to significantly impact survival in several
hematologic malignancies. We analyzed the prognostic value of the most frequent …

Nucleoside analogues (NA) are essential components of AML induction therapy (cytosine
arabinoside), effective treatments of lymphoproliferative disorders (fludarabine, cladribine) …

Cytotoxic nucleoside analogues and nucleobases were among the first chemotherapeutic
agents to be introduced for the medical treatment of cancer. This family of compounds has …

… Certain relationships marked with a “U” are those for which no compensation was received;
those relationships marked with a “C” were compensated. For a detailed description of the …

Mucosa-associated lymphoid tissue–derived lymphoma (MALT lymphoma) is usually a very
indolent lymphoma, described as localized at diagnosis and remaining localized for a …

… The six mammalian beta-tubulin isotypes may be grouped into six classes, according to
their C-terminal amino acid composition, which is the most highly divergent portion between …