Leflunomide (Arava) has recently been approved by the Food and Drug Administration for
the treatment of rheumatoid arthritis (RA). This approval was based on data from a double-…

Like apoptosis, oncogene-induced senescence is a barrier to tumor development. However,
relatively little is known about the signaling pathways mediating the senescence response. …

… (C) Individual data for carcinomas and adenomas sorted by methylation frequency. A white
box indicates unmethylated status and a black box methylated status. The methylation status …

… (c) Addition of uridine up to 8 hours after A77-1726 will still reverse the block of incorporation
of 3H-labelled thymidine into stimulated lymphocytes. From Cao et al.[1] (panels a and b) …

… incubated in the water bath at 37 C. Then the agar was diluted … Then the plates were placed
at 4 C for 30 min and 37 C for … at 4 C for 30 min, the plates were cultured at 37 C incubator …

… Membranes were blocked in 5% milk in TBS-T for one hour and incubated overnight at 4 C
with … or His tagged beads overnight at 4 C. Lysates were boiled at 95 C for 10 min to denature …

… (C) Images and quantifications of mammosphere formation of vector or TAZ-4SA transduced
MCF10A cells. Bars denote standard errors (n = 6). Representative images are shown. …

… We named this phenomenon chromatin-trapping or c-trapping. Although curaxins do not
bind and inhibit FACT directly, they cause exhaustion of FACT by trapping it in heterochromatin. …

Genetic and epigenetic alterations have been identified as to contribute directly or indirectly
to the generation of transitional cell carcinoma of the urinary bladder (TCC-UB). We have …

… USPs have a highly conserved USP domain, which allows direct binding to ubiquitin.4, 5,
6 The second family of DUBs, ubiquitin c-terminal hydrolases (UCHs), is named for their C-…