The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II: peptide complexes

…, P Menges, JM Weaver, CA Lazarski - Immunological …, 2005 - Wiley Online Library
… To measure dissociation rates, peptide and MHC protein are incubated at 37 C at pH 5.3 …
chromatography at 4 C. Purified peptide:MHC complexes are then incubated at 37 C in the …

[PDF][PDF] The kinetic stability of MHC class II: peptide complexes is a key parameter that dictates immunodominance

CA Lazarski, FA Chaves, SA Jenks, S Wu, KA Richards… - Immunity, 2005 - cell.com
… A second advantage of the HA (126–138) peptide is its intermediate with fluorescently
labeled peptide in vitro at endosomal pH 5.3 and 37C. Dissociation was found to fit a single …

[HTML][HTML] A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy

…, CA Lazarski, P Zhang, X Wang, P Ye, C Wang… - Cell research, 2018 - nature.com
… Data shown in c and d are representative of those from three mice per group and have
been repeated once. e In human CTLA4 homozygous mice, L3D10 but not Ipilimumab-induced …

SARS-CoV-2–specific T cells are rapidly expanded for therapeutic use and target conserved regions of the membrane protein

…, VV Kankate, H Lang, CA Lazarski… - Blood, The Journal …, 2020 - ashpublications.org
T-cell responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have
been described in recovered patients, and may be important for immunity following infection …

[HTML][HTML] Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B

MW Hogarth, A Defour, C Lazarski, E Gallardo… - Nature …, 2019 - nature.com
c Confocal images of LGMD2B patient muscle sections showing that perilipin-1 marked
lipid deposits (red) accumulate outside the boundaries of laminin-marked myofiber borders (…

High-intensity focused ultrasound (HIFU) triggers immune sensitization of refractory murine neuroblastoma to checkpoint inhibitor therapy

…, P Srinivasan, M Ries, AR Kim, CA Lazarski… - Clinical Cancer …, 2020 - AACR
… -controlled three-dimensional positioning system, and the lower half of the mouse's body
is submerged into a water bath filled with circulating degassed water at approximately 33C. …

[HTML][HTML] Robust antibody and T cell responses to SARS-CoV-2 in patients with antibody deficiency

…, VV Kankate, H Lang, CA Lazarski… - Journal of Clinical …, 2021 - Springer
… reported compound heterozygous variants in TNFRSF13B (c.310 T > C, p.Cys104Arg and
… , nucleocapsid, and spike are presented graphically (c) for antibody-deficient (in black) and …

Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine design

…, FA Chaves, FR Krafcik, CA Lazarski… - Expert review of …, 2007 - Taylor & Francis
CD4 T cells play a primary role in regulating immune responses to pathogenic organisms and
to vaccines. Antigen-specific CD4 T cells provide cognate help to B cells, a requisite event …

[HTML][HTML] IL-4 attenuates Th1-associated chemokine expression and Th1 trafficking to inflamed tissues and limits pathogen clearance

CA Lazarski, J Ford, SD Katzman, AF Rosenberg… - PloS one, 2013 - journals.plos.org
… BALB/c mice were immunized in ear dermis with 10 µL of 1 mg/mL OVA protein (Sigma-…
BALB/c mice were infected in ear dermis with 2×10 5 infectious Leishmania major promastigotes …

[HTML][HTML] Secondary bone marrow graft loss after third-party virus-specific T cell infusion: Case report of a rare complication

…, MA Jensen-Wachspress, CA Lazarski… - Nature …, 2024 - nature.com
C for 20 minutes, after which 10 mL of complete media was added to the cell suspension
and subsequently incubated at 37 C … Target cells were incubated at 37 C for 20 minutes, after …