From telomere to telomere: The transcriptional and epigenetic state of human repeat elements

…, PGS Grady, A Gershman, LG de Lima, C Limouse… - Science, 2022 - science.org
Mobile elements and repetitive genomic regions are sources of lineage-specific genomic
innovation and uniquely fingerprint individual genomes. Comprehensive analyses of such …

Dentate gyrus mossy cells control spontaneous convulsive seizures and spatial memory

AD Bui, TM Nguyen, C Limouse, HK Kim, GG Szabo… - Science, 2018 - science.org
… (C to F) Light delivery to the dorsal or ventral DG of ArchT-expressing mice [(C) and (D)]
and to the dorsal or ventral DG of ChR2-expressing mice [(E) and (F)]. (Left) Cumulative …

A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation

…, A Adhikari, CY Chiang, P Lis, E Purlyte, C Limouse… - Elife, 2022 - elifesciences.org
Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease,
and previously we showed that activated LRRK2 phosphorylates a subset of Rab GTPases (…

Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase

…, F Tonelli, WM Yeshaw, CY Chiang, C Limouse… - Elife, 2023 - elifesciences.org
Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease.
LRRK2 phosphorylates a subset of Rab GTPases, particularly Rab10 and Rab8A, and we …

[PDF][PDF] Xenopus laevis M18BP1 directly binds existing CENP-A nucleosomes to promote centromeric chromatin assembly

BT French, FG Westhorpe, C Limouse, AF Straight - Developmental cell, 2017 - cell.com
… binding motif in CENP-C, and we show that CENP-C competes with M18BP1 for CENP-A
nucleosome binding at centromeres. We show that both CENP-C and M18BP1 recruit HJURP …

Protein flexibility is required for vesicle tethering at the Golgi

PP Cheung, C Limouse, H Mabuchi, SR Pfeffer - Elife, 2015 - elifesciences.org
… They are anchored to the Golgi via their C-termini, and models suggest that they protrude
long distances, relying on the relative rigidity of the coiled coil structure to provide a meshwork …

The structure of DNA overstretched from the 5′ 5′ ends differs from the structure of DNA overstretched from the 3′ 3′ ends

C Danilowicz, C Limouse, K Hatch… - Proceedings of the …, 2009 - National Acad Sciences
… 1C) that is detected as a rapid movement of the bead away from the surface in the direction
of the force. To analyze force-induce melting in detail, a set of molecules was first placed …

[HTML][HTML] Global mapping of RNA-chromatin contacts reveals a proximity-dominated connectivity model for ncRNA-gene interactions

C Limouse, OK Smith, D Jukam, KA Fryer… - Nature …, 2023 - nature.com
… -C maps into genes while keeping the other dimension as genomic bins. In these transformed
Hi-C maps, … We detected in the ChAR-seq maps the same plaid pattern found in Hi-C data …

Kinetic and thermodynamic framework for P4-P6 RNA reveals tertiary motif modularity and modulation of the folding preferred pathway

N Bisaria, M Greenfeld, C Limouse… - Proceedings of the …, 2016 - National Acad Sciences
… (C) Proposed thermodynamic and kinetic framework based on previously identified structural
intermediates. P4-P6 is shown in a schematic depiction, color-coded as in A and B, and …

Identification and characterization of centromeric sequences in Xenopus laevis

OK Smith, C Limouse, KA Fryer, NA Teran… - Genome …, 2021 - genome.cshlp.org
… 2C,C′). These likely correspond to FCR monomers occupying distinct chromosomes. Other
pairs of FCR monomers were observed on a common set of chromosomes but to a different …