Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by
hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80% 1 , 2 . …

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

In this article, research on the natural course of illness among first-admission schizophrenic
patients is reviewed from an epidemiological perspective. Three types of studies are …

Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …

… Defining c j as the association statistic observed at marker j genotyped in n j cases and m
j controls and f as the χ 2 distribution with 1 degree of freedom, the likelihood of a given …

As technology advances, whole genome sequencing (WGS) is likely to supersede other
genotyping technologies. The rate of this change depends on its relative cost and utility. …

The potential for genome-wide association studies to relate phenotypes to specific genetic
variation is greatly increased when data can be combined or compared across multiple …

Obsessive-compulsive disorder (OCD) is a common, debilitating neuropsychiatric illness
with complex genetic etiology. The International OCD Foundation Genetics Collaborative (…

Importance Although early mortality in severe psychiatric illness is linked to smoking and
alcohol, to our knowledge, no studies have comprehensively characterized substance use …

A genome scan meta-a nalysis (GSMA) was carried out on 32 independent genome-wide
linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with …