Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome P450
2D6 (CYP2D6); hence, the efficacy and safety of codeine are governed by CYP2D6 activity…

Opioids are mainly used to treat both acute and chronic pain. Several opioids are metabolized
to some extent by CYP2D6 (codeine, tramadol, hydrocodone, oxycodone, and methadone…

5-hydroxytryptamine type 3 (5-HT 3) receptor antagonists are used in the prevention of
chemotherapy-induced, radiation-induced and postoperative nausea and vomiting. CYP2D6 …

… c. Participation in research studies should be noncoercive and respectful of participant … c.
Research studies intended to examine practices for the return of genomic information should …

We describe here the design and initial implementation of the eMERGE‐PGx project.
eMERGE‐PGx, a partnership of the Electronic Medical Records and Genomics Network and the …

… (c) Image of the optic disc from patient UK II-2 showing primary temporal optic nerve pallor
… found no ragged red fibers or cytochrome c oxidase (COX)-negative fibers (data not shown). …

Genetic variation can affect drug response in multiple ways, although it remains unclear how
rare genetic variants affect drug response. The electronic Medical Records and Genomics (…

… Prows MSN, CNS, FAAN , Janet K. Williams PhD, RN, PNP, FAAN , Shu-Fen Wung PhD,
RN, ACNP, FAHA, FAAN … LAMIN A/C; LMNA, 2008. Available at: http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=150330 …

Purpose Assessing the risk of common, complex diseases requires consideration of clinical
risk factors as well as monogenic and polygenic risks, which in turn may be reflected in …

BACKGROUND: Interindividual variability in pain perception and analgesic response is a
major problem in perioperative practice. Adult studies suggest pain management is influenced …