User profiles for C. Schurmann
Claudia SchurmannBayer AG, Pharmaceuticals Verified email at bayer.com Cited by 16937 |
Systematic identification of trans eQTLs as putative drivers of known disease associations
Identifying the downstream effects of disease-associated SNPs is challenging. To help
overcome this problem, we performed expression quantitative trait locus (eQTL) meta-analysis in …
overcome this problem, we performed expression quantitative trait locus (eQTL) meta-analysis in …
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
…, I Ntalla, V Nylander, S Schönherr, C Schurmann… - Nature …, 2018 - nature.com
We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130
European-descent individuals (9% cases), after imputation to high-density reference panels. …
European-descent individuals (9% cases), after imputation to high-density reference panels. …
Genetic analyses of diverse populations improves discovery for complex traits
Genome-wide association studies (GWAS) have laid the foundation for investigations into the
biology of complex traits, drug development and clinical guidelines. However, the majority …
biology of complex traits, drug development and clinical guidelines. However, the majority …
[HTML][HTML] Genetic and pharmacologic inactivation of ANGPTL3 and cardiovascular disease
…, C O'Dushlaine, C Schurmann… - … England Journal of …, 2017 - Mass Medical Soc
Background Loss-of-function variants in the angiopoietin-like 3 gene (ANGPTL3) have been
associated with decreased plasma levels of triglycerides, low-density lipoprotein (LDL) …
associated with decreased plasma levels of triglycerides, low-density lipoprotein (LDL) …
[HTML][HTML] A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease
…, X Cheng, AH Li, Y Xin, C Schurmann… - … England Journal of …, 2018 - Mass Medical Soc
Background Elucidation of the genetic factors underlying chronic liver disease may reveal
new therapeutic targets. Methods We used exome sequence data and electronic health …
new therapeutic targets. Methods We used exome sequence data and electronic health …
Rare and low-frequency coding variants alter human adult height
Height is a highly heritable, classic polygenic trait with approximately 700 common associated
variants identified through genome-wide association studies so far. Here, we report 83 …
variants identified through genome-wide association studies so far. Here, we report 83 …
[HTML][HTML] The transcriptional landscape of age in human peripheral blood
Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …
to increased disease susceptibility remain inadequately understood. Here we perform a …
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
…, R Nagaraja, MG Piras, M Nauck, C Schurmann… - Nature …, 2013 - nature.com
Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory
arthritis. By combining data from >140,000 individuals of European ancestry within the Global …
arthritis. By combining data from >140,000 individuals of European ancestry within the Global …
Neuroanatomy of autism
DG Amaral, CM Schumann, CW Nordahl - Trends in neurosciences, 2008 - cell.com
… ) total brain volume, (b) gray matter and (c) white matter, based on existing MRI literature. Only
… ] show greater increases in white matter than gray matter (Figure 2b,c). But again, whether …
… ] show greater increases in white matter than gray matter (Figure 2b,c). But again, whether …
[HTML][HTML] Exome sequencing and characterization of 49,960 individuals in the UK Biobank
…, C O'Dushlaine, A Marcketta, J Staples, C Schurmann… - Nature, 2020 - nature.com
The UK Biobank is a prospective study of 502,543 individuals, combining extensive phenotypic
and genotypic data with streamlined access for researchers around the world 1 . Here …
and genotypic data with streamlined access for researchers around the world 1 . Here …