[PDF][PDF] Role of laminins in physiological and pathological angiogenesis

…, G Orend, E Mammadova-Bach, C Spenlé… - International journal of …, 2011 - academia.edu
The interaction of endothelial cells and pericytes with their microenvironment, in particular
with the basement membrane, plays a crucial role during vasculogenesis and angiogenesis. …

Laminin α5 guides tissue patterning and organogenesis

C Spenlé, P Simon-Assmann, G Orend… - Cell adhesion & …, 2013 - Taylor & Francis
… The base of the cross is formed by the C-terminal part of the α chain called the laminin
globular (LG) domain, which is subdivided into five globular subdomains (LG1-LG5).Citation 14 …

Tenascin-C: Exploitation and collateral damage in cancer management

C Spenlé, F Saupe, K Midwood, H Burckel… - Cell adhesion & …, 2015 - Taylor & Francis
… of tenascin-C could be exploited for diagnosis and targeting because tenascin-C is highly
… tumorigenesis model displaying either abundant or no tenascin-C.Citation 4 Here tenascin-…

[PDF][PDF] Autonomous extracellular matrix remodeling controls a progressive adaptation in muscle stem cell regenerative capacity during development

MT Tierney, A Gromova, FB Sesillo, D Sala, C Spenlé… - Cell reports, 2016 - cell.com
… their microenvironment with the production of tenascin-C, fibronectin, and collagen VI. …
maintaining comparable levels of Pax7 expression (Figure 1C). At the protein level, fetal MuSCs …

[PDF][PDF] Enterocyte purge and rapid recovery is a resilience reaction of the gut epithelium to pore-forming toxin attack

…, C Socha, S Schirmeier, A Schmitz, C Spenlé… - Cell Host & Microbe, 2016 - cell.com
… Flies were shifted from 18 C to 29 C for 6 days prior to mock or oral SmDb11 infection. …
Survivals were performed at 25 C (29 C for experiments involving the Gal4 overexpression system…

[PDF][PDF] Tenascin-C downregulates wnt inhibitor dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model

F Saupe, A Schwenzer, Y Jia, I Gasser, C Spenlé… - Cell reports, 2013 - cell.com
The extracellular matrix molecule tenascin-C (TNC) is a major component of the cancer-specific
matrix, and high TNC expression is linked to poor prognosis in several cancers. To …

Tenascin-C orchestrates an immune-suppressive tumor microenvironment in oral squamous cell carcinoma

C Spenlé, T Loustau, D Murdamoothoo, W Erne… - Cancer Immunology …, 2020 - AACR
… Using a 4NQO-induced oral squamous cell carcinoma (OSCC) model with abundant and
absent tenascin-C, we demonstrated that tenascin-C enforced an immune-suppressive …

[HTML][HTML] Transmembrane domain targeting peptide antagonizing ErbB2/Neu inhibits breast tumor growth and metastasis

A Arpel, P Sawma, C Spenle, J Fritz, L Meyer… - Cell reports, 2014 - cell.com
Breast cancer is still a deadly disease despite major achievements in targeted therapies
designed to block ligands or ligand-binding subunits of major tyrosine kinase receptors. …

[HTML][HTML] Tenascin-C increases lung metastasis by impacting blood vessel invasions

…, D Murdamoothoo, C Ahowesso, A Yilmaz, C Spenlé… - Matrix Biology, 2019 - Elsevier
… or tenascin-C knockout mice. We show that stromal-derived tenascin-C increases metastasis
… We found extracellular matrix, in particular, tenascin-C, between the stromal cells and the …

Disruption of Sema3A/Plexin‐A1 inhibitory signalling in oligodendrocytes as a therapeutic strategy to promote remyelination

F Binamé, LD Pham‐Van, C Spenlé… - EMBO molecular …, 2019 - embopress.org
… The following programme was used: 95C for 10 min, followed by 40 cycles of 95C for 30 s,
and polymerization at 60C for 1 min. MBP expression was monitored after 4 days of …