Objective: To assess the importance of vascular cognitive impairment and its three subgroups
(cognitive impairment, no dementia; vascular dementia; and AD with a vascular component…

Little is known about progression, short of dementia, in vascular cognitive impairment. In the
Canadian Study of Health and Aging, 149 participants (79.3 ± 6.7 years; 61% women) were …

The increased rate of fetal malformation in diabetic pregnancy represents both a clinical
problem and a research challenge. In recent years, experimental and clinical studies have given …

… The reaction was incubated overnight at 37 C. Unincorporated nucleotides were removed
using the BioPrime purification kit (GE HealthCare, UK). Labelled test and reference DNA …

Micro RNA s (mi RNA s) regulate target mRNA s by silencing them. Reciprocally, however,
target mRNA s can also modulate mi RNA stability. Here, we uncover a remarkable efficacy of …

Background— Vascular cognitive impairment that does not fulfill dementia criteria (ie, vascular
cognitive impairment, no dementia [CIND]) is common. Although progression to dementia …

Toward understanding topographically specific branching of retinal axons in their target area,
we have studied the interaction between neurotrophin receptors and members of the Eph …

Background Quality of antidepressant treatment remains disturbingly poor. Rates of
medication adherence and follow-up contact are especially low in primary care, where most …

Background In the phase III IMpassion130 trial, combining atezolizumab with first-line
nanoparticle albumin-bound-paclitaxel for advanced triple-negative breast cancer (aTNBC) …

If vascular risk factors are risks for Alzheimer's disease (AD), and if “pure” vascular dementia
(VaD) is less common than has been thought, what do we make of the diagnosis of mixed …