User profiles for D. A. Hartmann

David Anthony Hartmann

- Verified email at stanford.edu - Cited by 1646

Diego Hartmann

- Verified email at unipampa.edu.br - Cited by 148

Pericyte control of blood flow across microvascular zones in the central nervous system

DA Hartmann, V Coelho-Santos… - Annual review of …, 2022 - annualreviews.org
The vast majority of the brain's vascular length is composed of capillaries, where our
understanding of blood flow control remains incomplete. This review synthesizes current …

[HTML][HTML] Pericyte structural remodeling in cerebrovascular health and homeostasis

AA Berthiaume, DA Hartmann, MW Majesky… - Frontiers in aging …, 2018 - frontiersin.org
The biology of brain microvascular pericytes is an active area of research and discovery, as
their interaction with the endothelium is critical for multiple aspects of cerebrovascular …

Brain capillary pericytes exert a substantial but slow influence on blood flow

DA Hartmann, AA Berthiaume, RI Grant, SA Harrill… - Nature …, 2021 - nature.com
The majority of the brain’s vasculature is composed of intricate capillary networks lined by
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …

Pericyte structure and distribution in the cerebral cortex revealed by high-resolution imaging of transgenic mice

DA Hartmann, RG Underly, RI Grant… - …, 2015 - spiedigitallibrary.org
Pericytes are essential for normal brain function, but many aspects of their physiology
remain enigmatic due to a lack of tools to genetically target this cell population. Here, we …

Does pathology of small venules contribute to cerebral microinfarcts and dementia?

DA Hartmann, HI Hyacinth, FF Liao… - Journal of …, 2018 - Wiley Online Library
Microinfarcts are small, but strikingly common, ischemic brain lesions in the aging human
brain. There is mounting evidence that microinfarcts contribute to vascular cognitive …

Organizational hierarchy and structural diversity of microvascular pericytes in adult mouse cortex

RI Grant, DA Hartmann, RG Underly… - Journal of Cerebral …, 2019 - journals.sagepub.com
Smooth muscle cells and pericytes, together called mural cells, coordinate many distinct
vascular functions. Canonically, smooth muscle cells are ring-shaped and cover arterioles with …

[PDF][PDF] Dynamic remodeling of pericytes in vivo maintains capillary coverage in the adult mouse brain

…, RI Grant, KP McDowell, RG Underly, DA Hartmann… - Cell reports, 2018 - cell.com
Direct contact and communication between pericytes and endothelial cells is critical for
maintenance of cerebrovascular stability and blood-brain barrier function. Capillary pericytes …

Pericytes as inducers of rapid, matrix metalloproteinase-9-dependent capillary damage during ischemia

RG Underly, M Levy, DA Hartmann… - Journal of …, 2017 - Soc Neuroscience
Blood–brain barrier disruption (BBB) and release of toxic blood molecules into the brain
contributes to neuronal injury during stroke and other cerebrovascular diseases. While pericytes …

Functional deficits induced by cortical microinfarcts

PM Summers, DA Hartmann, ES Hui… - Journal of Cerebral …, 2017 - journals.sagepub.com
Clinical studies have revealed a strong link between increased burden of cerebral
microinfarcts and risk for cognitive impairment. Since the sum of tissue damage incurred by …

[HTML][HTML] VasoMetrics: unbiased spatiotemporal analysis of microvascular diameter in multi-photon imaging applications

…, AA Berthiaume, T Tieu, DA Hartmann… - … Imaging in Medicine …, 2021 - ncbi.nlm.nih.gov
Background Multi-photon imaging of the cerebrovasculature provides rich data on the
dynamics of cortical arterioles, capillaries, and venules. Vascular diameter is the major …