Pericyte control of blood flow across microvascular zones in the central nervous system
DA Hartmann, V Coelho-Santos… - Annual review of …, 2022 - annualreviews.org
The vast majority of the brain's vascular length is composed of capillaries, where our
understanding of blood flow control remains incomplete. This review synthesizes current …
understanding of blood flow control remains incomplete. This review synthesizes current …
[HTML][HTML] Pericyte structural remodeling in cerebrovascular health and homeostasis
AA Berthiaume, DA Hartmann, MW Majesky… - Frontiers in aging …, 2018 - frontiersin.org
The biology of brain microvascular pericytes is an active area of research and discovery, as
their interaction with the endothelium is critical for multiple aspects of cerebrovascular …
their interaction with the endothelium is critical for multiple aspects of cerebrovascular …
Brain capillary pericytes exert a substantial but slow influence on blood flow
The majority of the brain’s vasculature is composed of intricate capillary networks lined by
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …
Pericyte structure and distribution in the cerebral cortex revealed by high-resolution imaging of transgenic mice
DA Hartmann, RG Underly, RI Grant… - …, 2015 - spiedigitallibrary.org
Pericytes are essential for normal brain function, but many aspects of their physiology
remain enigmatic due to a lack of tools to genetically target this cell population. Here, we …
remain enigmatic due to a lack of tools to genetically target this cell population. Here, we …
Does pathology of small venules contribute to cerebral microinfarcts and dementia?
DA Hartmann, HI Hyacinth, FF Liao… - Journal of …, 2018 - Wiley Online Library
Microinfarcts are small, but strikingly common, ischemic brain lesions in the aging human
brain. There is mounting evidence that microinfarcts contribute to vascular cognitive …
brain. There is mounting evidence that microinfarcts contribute to vascular cognitive …
Organizational hierarchy and structural diversity of microvascular pericytes in adult mouse cortex
RI Grant, DA Hartmann, RG Underly… - Journal of Cerebral …, 2019 - journals.sagepub.com
Smooth muscle cells and pericytes, together called mural cells, coordinate many distinct
vascular functions. Canonically, smooth muscle cells are ring-shaped and cover arterioles with …
vascular functions. Canonically, smooth muscle cells are ring-shaped and cover arterioles with …
[PDF][PDF] Dynamic remodeling of pericytes in vivo maintains capillary coverage in the adult mouse brain
Direct contact and communication between pericytes and endothelial cells is critical for
maintenance of cerebrovascular stability and blood-brain barrier function. Capillary pericytes …
maintenance of cerebrovascular stability and blood-brain barrier function. Capillary pericytes …
Pericytes as inducers of rapid, matrix metalloproteinase-9-dependent capillary damage during ischemia
RG Underly, M Levy, DA Hartmann… - Journal of …, 2017 - Soc Neuroscience
Blood–brain barrier disruption (BBB) and release of toxic blood molecules into the brain
contributes to neuronal injury during stroke and other cerebrovascular diseases. While pericytes …
contributes to neuronal injury during stroke and other cerebrovascular diseases. While pericytes …
Functional deficits induced by cortical microinfarcts
PM Summers, DA Hartmann, ES Hui… - Journal of Cerebral …, 2017 - journals.sagepub.com
Clinical studies have revealed a strong link between increased burden of cerebral
microinfarcts and risk for cognitive impairment. Since the sum of tissue damage incurred by …
microinfarcts and risk for cognitive impairment. Since the sum of tissue damage incurred by …
[HTML][HTML] VasoMetrics: unbiased spatiotemporal analysis of microvascular diameter in multi-photon imaging applications
…, AA Berthiaume, T Tieu, DA Hartmann… - … Imaging in Medicine …, 2021 - ncbi.nlm.nih.gov
Background Multi-photon imaging of the cerebrovasculature provides rich data on the
dynamics of cortical arterioles, capillaries, and venules. Vascular diameter is the major …
dynamics of cortical arterioles, capillaries, and venules. Vascular diameter is the major …