Interaction of depression and anxiety in the development of mixed anxiety/depression disorder. Experimental studies of the mechanisms of comorbidity

AG Galyamina, IL Kovalenko, DA Smagin… - Neuroscience and …, 2017 - Springer
The symptoms of depression and anxiety often accompany each other. This is apparent both
in clinical practice and in laboratory studies. The combination of anxiety and depression in …

Repeated positive fighting experience in male inbred mice

NN Kudryavtseva, DA Smagin, IL Kovalenko… - Nature protocols, 2014 - nature.com
Repeated aggression is a frequent symptom of many psychiatric and neurological disorders,
including obsessive-compulsive and attention deficit hyperactivity disorders, bipolar and …

[HTML][HTML] Dysfunction in ribosomal gene expression in the hypothalamus and hippocampus following chronic social defeat stress in male mice as revealed by RNA-Seq

DA Smagin, IL Kovalenko, AG Galyamina, AO Bragin… - Neural …, 2016 - hindawi.com
Chronic social defeat stress leads to the development of anxiety- and depression-like states
in male mice and is accompanied by numerous molecular changes in brain. The influence …

[HTML][HTML] Altered Slc25 family gene expression as markers of mitochondrial dysfunction in brain regions under experimental mixed anxiety/depression-like disorder

VN Babenko, DA Smagin, AG Galyamina… - BMC neuroscience, 2018 - Springer
Background Development of anxiety- and depression-like states under chronic social defeat
stress in mice has been shown by many experimental studies. In this article, the …

[HTML][HTML] Chronic Lithium Treatment affects anxious behaviors and theExpression of serotonergic genes in Midbrain Raphe nuclei of defeated male mice

DA Smagin, IL Kovalenko, AG Galyamina… - Biomedicines, 2021 - mdpi.com
There is experimental evidence that chronic social defeat stress is accompanied by the
development of an anxiety, development of a depression-like state, and downregulation of …

[HTML][HTML] Extended effect of chronic social defeat stress in childhood on behaviors in adulthood

IL Kovalenko, AG Galyamina, DA Smagin… - PloS one, 2014 - journals.plos.org
Individuals exposed to social stress in childhood are more predisposed to developing
psychoemotional disorders in adulthood. Here we use an animal model to determine the influence …

[HTML][HTML] Altered hippocampal neurogenesis and amygdalar neuronal activity in adult mice with repeated experience of aggression

DA Smagin, JH Park, TV Michurina… - Frontiers in …, 2015 - frontiersin.org
Repeated experience of winning in a social conflict setting elevates levels of aggression and
may lead to violent behavioral patterns. Here, we use a paradigm of repeated aggression …

Serotonergic genes in the development of anxiety/depression-like state and pathology of aggressive behavior in male mice: RNA-seq data

NN Kudryavtseva, DA Smagin, IL Kovalenko… - Molecular biology, 2017 - Springer
In course of daily agonistic interactions, mice tend to stratify into those with chronic social
defeats and those that repeatedly display aggression, which lead to the development of mixed …

[HTML][HTML] Altered Expression of Genes Associated with Major Neurotransmitter Systems in the Reward-Related Brain Regions of Mice with Positive Fighting Experience

DA Smagin, AG Galyamina, IL Kovalenko… - International Journal of …, 2022 - mdpi.com
… , release GABA or glutamate in addition to DA [70,71]. DA is a key neurotransmitter in reward
… to other regions with the help of DA [81], particularly, to the regions we are interested in. …

[HTML][HTML] Dopamine response gene pathways in dorsal striatum MSNs from a gene expression viewpoint: cAMP-mediated gene networks

VN Babenko, AG Galyamina, IB Rogozin, DA Smagin… - BMC neuroscience, 2020 - Springer
… Single gene corresponding to DA depletion is represented … of D1 MSN, and D2/DA-depleted
states. Blue dotted arrow … states of D1 MSN, and D2/DA-depleted states. Cluster—specific …