Autophagy is an important biological process that is essential for the removal of damaged
organelles and toxic or aggregated proteins by delivering them to the lysosome for degradation…

… The SENP family of enzymes is responsible for the de-SUMOylation of htt. (B) Alternatively,
lysines 6, 9, and 15 of htt can be ubiquitinated by E3 ligases, including E2-25K, which directs …

Caspases are cysteine-aspartic proteases that post-translationally modify their substrates
through cleavage at specific sites, which causes either substrate inactivation or a gain of …

The accumulation of β-sheet–rich amyloid fibrils or aggregates is a complex, multistep process
that is associated with cellular toxicity in a number of human protein misfolding disorders, …

Protein misfolding and formation of β-sheet-rich amyloid fibrils or aggregates is related to
cellular toxicity and decay in various human disorders including Alzheimer’s and Parkinson’s …

Huntington's disease is caused by an expanded CAG repeat in the gene encoding huntingtin
(HTT), resulting in loss of striatal and cortical neurons. Given that the gene product is …

Huntington's disease (HD) is a progressive neurodegenerative disorder for which only
symptomatic treatments of limited effectiveness are available. Preventing early misfolding steps …

Levels of full-length huntingtin (FL htt) influence organ and body weight, independent of
polyglutamine length. The growth hormone-insulin like growth factor-1 (GH-IGF-1) axis is well …

An accepted prerequisite for clinical trials of a compound in humans is the successful alleviation
of the disease in animal models. For some diseases, however, successful translation of …

… We therefore tested whether HACE1 promotes NRF2 protein synthesis, as NRF2 nuclear
localization under oxidative stress is dependent on de novo NRF2 synthesis (22). To compare …