BACKGROUND Complete surgical removal of the prostate, radical prostatectomy, is the
most frequently used treatment option for men with localised prostate cancer. The use of …

Benign prostatic hyperplasia (BPH) is one of the most common conditions affecting men. BPH
can lead to a number of symptoms for patients commonly referred to as lower urinary tract …

Background: Disturbed folate metabolism is associated with an increased risk of some cancers.
Our objective was to determine whether blood levels of folate, vitamin B 12 , and related …

Background The comparative effectiveness of treatments for prostate cancer that is detected
by prostate-specific antigen (PSA) testing remains uncertain. Methods We compared active …

… Subsequent studies have shown stable survival statistics despite reduced PSA testing and
an increased incidence of regional or advanced prostate cancer in the United States.Our trial …

… Metastasis-to-metastasis spread was found to be common, either through de novo monoclonal
seeding of daughter metastases or, in five cases, through the transfer of multiple tumour …

Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified
more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data …

Stem cells are clonogenic cells with self-renewal and differentiation properties, which may
represent a major target for genetic damage leading to prostate cancer and benign prostatic …

Background Robust data on patient-reported outcome measures comparing treatments for
clinically localized prostate cancer are lacking. We investigated the effects of active monitoring…

Prostate cancer is the most common cancer affecting males in developed countries. It shows
consistent evidence of familial aggregation, but the causes of this aggregation are mostly …