Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates
the maturation of a wide range of proteins (known as clients). Clients are enriched in signal …

Changing a single nucleotide in a genome can have profound consequences under some
conditions, but the same change can have no consequences under others. Indeed, …

… We thank members of the Jarosz laboratory for helpful comments and suggestions and
apologize to those whose work we could not cite due to space limitations. ZHH is supported by …

The self-templating conformations of yeast prion proteins act as epigenetic elements of
inheritance. Yeast prions might provide a mechanism for generating heritable phenotypic …

… To investigate the generality of these claims, Jarosz and Lindquist (p. 1820) screened 96
Saccharomyces cerevisiae strains from various ecological niches—soil, fruit, sake, beer, and …

In the process of morphological evolution, the extent to which cryptic, preexisting variation
provides a substrate for natural selection has been controversial. We provide evidence that …

Translesion synthesis (TLS) by Y-family DNA polymerases is a chief mechanism of DNA
damage tolerance 1 . Such TLS can be accurate or error-prone, as it is for bypass of a …

Prions are a paradigm-shifting mechanism of inheritance in which phenotypes are encoded
by self-templating protein conformations rather than nucleic acids. Here, we examine the …

In experimental science, organisms are usually studied in isolation, but in the wild, they
compete and cooperate in complex communities. We report a system for cross-kingdom …

The observation that mutations in the Escherichia coli genes umuC + and umuD + abolish
mutagenesis induced by UV light strongly supported the counterintuitive notion that such …