Although genetic association studies have been with us for many years, even for the simplest
analyses there is little consensus on the most appropriate statistical procedures. Here I …

Despite the success of genome-wide association studies (GWASs) in identifying loci associated
with common diseases, a substantial proportion of the causality remains unexplained. …

Established guidelines for causal inference in epidemiological studies may be inappropriate
for genetic associations. A consensus process was used to develop guidance criteria for …

… David Balding-Department of Epidemiology & Public Health, Imperial College An advisor
for our Probability & Statistics series, Professor Balding is also a previous Wiley author, having …

Type 2 diabetes mellitus results from the interaction of environmental factors with a combination
of genetic variants, most of which were hitherto unknown. A systematic search for these …

We propose a new method for approximate Bayesian statistical inference on the basis of
summary statistics. The method is suited to complex problems that arise in population genetics, …

The identification of signatures of natural selection in genomic surveys has become an area
of intense research, stimulated by the increasing ease with which genetic markers can be …

The paper is concerned with methods for the estimation of the coalescence time (time since
the most recent common ancestor) of a sample of intraspecies DNA sequences. The …

Genetic data obtained on population samples convey information about their evolutionary
history. Inference methods can extract part of this information but they require sophisticated …

Estimation of narrow-sense heritability, h 2 , from genome-wide SNPs genotyped in unrelated
individuals has recently attracted interest and offers several advantages over traditional …