The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS),
published in 2021, is the sixth version of the international standard for the classification of …

Interleukin-8 (IL-8, or CXCL8), which is a chemokine with a defining CXC amino acid motif
that was initially characterized for its leukocyte chemotactic activity, is now known to possess …

Glioblastomas, like other solid tumors, have extensive areas of hypoxia and necrosis. The
importance of hypoxia in driving tumor growth is receiving increased attention. Hypoxia-…

Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic
glioma driving alterations and suboptimal disease classification. We defined the complete …

Cancer histology reflects underlying molecular processes and disease progression and
contains rich phenotypic information that is predictive of patient outcomes. In this study, we show …

The brain tumor glioblastoma multiforme (GBM) is among the most lethal forms of human
cancer. Here, we report that a small subset of GBMs (3.1%; 3 of 97 tumors examined) harbors …

cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor
Taxonomy) was established to evaluate and make practical recommendations on recent …

The World Health Organization (WHO) central nervous system tumor classification represents
the primary source of updates on diagnostic classes, grades and criteria [17]. However, …

Glioblastoma (GBM) is a highly malignant, rapidly progressive astrocytoma that is distinguished
pathologically from lower grade tumors by necrosis and microvascular hyperplasia. …

The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of gliomas
and contributes to the failure of current therapeutic modalities (surgery, radiation and …