User profiles for D. M. Harkins

Derek M. Harkins

Associate Lead Scientist, Bioinformatics, Booz|Allen|Hamilton
Verified email at bah.com
Cited by 2643

[PDF][PDF] Host genetic control of the oral microbiome in health and disease

A Gomez, JL Espinoza, DM Harkins, P Leong… - Cell host & …, 2017 - cell.com
Host-associated microbial communities are influenced by both host genetics and environmental
factors. However, factors controlling the human oral microbiome and their impact on …

New insights into dissemination and variation of the health care-associated pathogen Acinetobacter baumannii from genomic analysis

MS Wright, DH Haft, DM Harkins, F Perez, KM Hujer… - MBio, 2014 - Am Soc Microbiol
Acinetobacter baumannii is a globally important nosocomial pathogen characterized by an
increasing incidence of multidrug resistance. Routes of dissemination and gene flow among …

Advances in microbiome research for animal health

RS Peixoto, DM Harkins… - Annual Review of Animal …, 2021 - annualreviews.org
Host-associated microbiomes contribute in many ways to the homeostasis of the metaorganism.
The microbiome's contributions range from helping to provide nutrition and aiding growth…

[HTML][HTML] Gastrointestinal microbial populations can distinguish pediatric and adolescent Acute Lymphoblastic Leukemia (ALL) at the time of disease diagnosis

SV Rajagopala, S Yooseph, DM Harkins, KJ Moncera… - BMC genomics, 2016 - Springer
Background An estimated 15,000 children and adolescents under the age of 19 years are
diagnosed with leukemia, lymphoma and other tumors in the USA every year. All children and …

[HTML][HTML] Stool microbiota composition is associated with the prospective risk of Plasmodium falciparum infection

S Yooseph, EF Kirkness, TM Tran, DM Harkins… - BMC genomics, 2015 - Springer
Background In humans it is unknown if the composition of the gut microbiota alters the risk of
Plasmodium falciparum infection or the risk of developing febrile malaria once P. falciparum …

[HTML][HTML] A novel method of consensus pan-chromosome assembly and large-scale comparative analysis reveal the highly flexible pan-genome of Acinetobacter …

…, Y Choi, XZ Huang, E Beck, DM Harkins… - Genome biology, 2015 - Springer
Background Infections by pan-drug resistant Acinetobacter baumannii plague military and
civilian healthcare systems. Previous A. baumannii pan-genomic studies used modest sample …

Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5

…, MS Wright, AH Lindell, DM Harkins… - Journal of …, 2008 - Am Soc Microbiol
The increasing occurrence of multidrug-resistant pathogens of clinical and agricultural
importance is a global public health concern. While antimicrobial use in human and veterinary …

[HTML][HTML] Whole Genome Analysis of Leptospira licerasiae Provides Insight into Leptospiral Evolution and Pathogenicity

…, DE Fouts, JD Selengut, DM Harkins… - PLoS neglected …, 2012 - journals.plos.org
The whole genome analysis of two strains of the first intermediately pathogenic leptospiral
species to be sequenced (Leptospira licerasiae strains VAR010 and MMD0835) provides …

Supragingival plaque microbiome ecology and functional potential in the context of health and disease

JL Espinoza, DM Harkins, M Torralba, A Gomez… - MBio, 2018 - Am Soc Microbiol
To address the question of how microbial diversity and function in the oral cavities of children
relates to caries diagnosis, we surveyed the supragingival plaque biofilm microbiome in 44 …

Analysis of the Aedes albopictus C6/36 genome provides insight into cell line utility for viral propagation

…, KA Dilley, V Puri, DM Brown, DM Harkins… - …, 2018 - academic.oup.com
Background The 50-year-old Aedes albopictus C6/36 cell line is a resource for the detection,
amplification, and analysis of mosquito-borne viruses including Zika, dengue, and …