Modern genetic approaches are powerful in providing access to diverse cell types in the brain
and facilitating the study of their function. Here, we report a large set of driver and reporter …

Transgenic mouse lines are invaluable tools for neuroscience but, as with any technique,
care must be taken to ensure that the tool itself does not unduly affect the system under study. …

… Finally, the measured thalamic firing statistics were used to drive a model of the thalamocortical
circuit, which demonstrated a sharpening effect with adaptation similar to that measured …

Cortical circuits can flexibly change with experience and learning, but the effects on specific
cell types, including distinct inhibitory types, are not well understood. Here we investigated …

… Individual sessions were analyzed to drive adjustments in the training parameters such as
the number of automatic ‘free’ rewards. Following data collection for all animals, all sessions …

… Cells from Esr2 and Gnb4 are well mixed, indicating that they drive similar populations in …
The inhibition tends to be overridden by the continuous drive in the 500 ms stimulation for …

The rapid detection of sensory inputs is crucial for survival. Sensory detection explicitly
requires the integration of incoming sensory information and the ability to distinguish between …

Electrical microstimulation has been widely used to artificially activate neural circuits on fast
time scales. Despite the ubiquity of its use, little is known about precisely how it activates …

… Images with more salient features (eg low-frequency, high-contrast edges) will strongly drive
the input units in our model, while less salient images will only drive the input units weakly. …

To study the mechanisms of perception and cognition, neural measurements must be made
during behavior. A goal of the Allen Brain Observatory is to map the activity of distinct cortical …