Background Respiratory failure due to COVID-19 pneumonia is associated with high mortality
and may overwhelm health care systems, due to the surge of patients requiring advanced …

The 3-O-sulfation of N-sulfated glucosamine is the last event in the biosynthesis of heparin/heparan
sulfate, giving rise to the antithrombin-binding pentasaccharide sequence AGA*IA, …

… -1,6-anhydro-d-mannosamine and N-sulfo-1,6-anhydro-d-glucosamine, respectively, has
been … Because of their moderate affinity, it was not possible to determine K d for the binding of …

The Zfp423/ZNF423 gene encodes a 30-zinc-finger transcription factor involved in key
developmental pathways. Although null Zfp423 mutants develop cerebellar malformations, the …

The antithrombin (AT) binding properties of heparin and low molecular weight heparins are
strongly associated to the presence of the pentasaccharide sequence AGA*IA (A NAc,6S -…

… -D-GlcA or α-L-IdoA) and α-D-glucosamine, with varying patterns of sulfation, at position-2
of the uronic acid (for iduronate denoted I-2) and/or -6 of the glucosamine (denoted A-6) units …

Background Benchmark analysis for open liver surgery for cirrhotic patients with hepatocellular
carcinoma (HCC) is still undefined. Methods Patients were identified from the Italian …

Peptides seldom retain stable conformations if separated from their native protein structure.
In an immunological context, this potentially affects the development of selective peptide-…

The first use of statistical correlation spectroscopy to extract chemical information from 2D-HSQC
spectra, termed HSQC correlation spectroscopy (HSQCcos), is reported. HSQCcos is …

In contrast to most pharmaceutical agents, the major anticoagulant agent, heparin, lacks a
uniquely defined chemical structure. It is an inherently structurally varying, poly-disperse …