User profiles for D. Gaykalova
Daria GaykalovaAssociate Professor of Otorhinolaryngology - Head and Neck Surgery, University of … Verified email at som.umaryland.edu Cited by 2880 |
Epigenetic regulation of gene expression in cancer: techniques, resources and analysis
Cancer is a complex disease, driven by aberrant activity in numerous signaling pathways in
even individual malignant cells. Epigenetic changes are critical mediators of these functional …
even individual malignant cells. Epigenetic changes are critical mediators of these functional …
[HTML][HTML] Molecular mechanisms of human papillomavirus-related carcinogenesis in head and neck cancer
This review examines the general cellular and molecular underpinnings of human
papillomavirus (HPV)-related carcinogenesis in the context of head and neck squamous cell …
papillomavirus (HPV)-related carcinogenesis in the context of head and neck squamous cell …
Transcription through chromatin by RNA polymerase II: histone displacement and exchange
OI Kulaeva, DA Gaykalova, VM Studitsky - Mutation Research/Fundamental …, 2007 - Elsevier
The process of transcript elongation by RNA polymerase II (Pol II) involves transcription-dependent
exchange and displacement of all core histones and is tightly controlled by …
exchange and displacement of all core histones and is tightly controlled by …
[HTML][HTML] Nucleosomes can form a polar barrier to transcript elongation by RNA polymerase II
VA Bondarenko, LM Steele, A Újvári, DA Gaykalova… - Molecular cell, 2006 - cell.com
Nucleosomes uniquely positioned on high-affinity DNA sequences present a polar barrier to
transcription by human and yeast RNA polymerase II (Pol II). In one transcriptional …
transcription by human and yeast RNA polymerase II (Pol II). In one transcriptional …
Activation of the NOTCH Pathway in Head and Neck Cancer
…, DA Gaykalova, MF Ochs, E Mambo, D Arnaoutakis… - Cancer research, 2014 - AACR
NOTCH1 mutations have been reported to occur in 10% to 15% of head and neck squamous
cell carcinomas (HNSCC). To determine the significance of these mutations, we embarked …
cell carcinomas (HNSCC). To determine the significance of these mutations, we embarked …
Mechanism of chromatin remodeling and recovery during passage of RNA polymerase II
OI Kulaeva, DA Gaykalova, NA Pestov… - Nature structural & …, 2009 - nature.com
… In summary, the P- and D-dimers have different roles within the same nucleosome. As
expected, removal of the P-dimer results in a strong Pol II arrest in the +45 region, most likely …
expected, removal of the P-dimer results in a strong Pol II arrest in the +45 region, most likely …
Using DNA mechanics to predict in vitro nucleosome positions and formation energies
AV Morozov, K Fortney, DA Gaykalova… - Nucleic acids …, 2009 - academic.oup.com
In eukaryotic genomes, nucleosomes function to compact DNA and to regulate access to it
both by simple physical occlusion and by providing the substrate for numerous covalent …
both by simple physical occlusion and by providing the substrate for numerous covalent …
[HTML][HTML] HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers
The dominant paradigm for HPV carcinogenesis includes integration into the host genome
followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic …
followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic …
[HTML][HTML] Novel insight into mutational landscape of head and neck squamous cell carcinoma
DA Gaykalova, E Mambo, A Choudhary, J Houghton… - PloS one, 2014 - journals.plos.org
Development of head and neck squamous cell carcinoma (HNSCC) is characterized by
accumulation of mutations in several oncogenes and tumor suppressor genes. We have formerly …
accumulation of mutations in several oncogenes and tumor suppressor genes. We have formerly …
[HTML][HTML] Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers
…, C Liu, S Haft, J Pang, A Mark, DA Gaykalova… - Nature …, 2019 - nature.com
… d Significance of DNA methylation increase in tumor. The red line represents the observed
AUC ratio (tumor/normal) at TSS ± 500 bp region. Gray bars represent the null distribution as …
AUC ratio (tumor/normal) at TSS ± 500 bp region. Gray bars represent the null distribution as …