Forkhead box P3 (FOXP3) + regulatory T (T Reg ) cells are potent mediators of dominant
self tolerance in the periphery. But confusion as to the identity, stability and suppressive …

… In addition, we have found that passively transferred anti-OVA antibodies prevented the
generation of high-dose OVA specific anergy-driven oral tolerance (D Melamed & A Friedman, in …

In recent years, the understanding of regulatory T cell (T reg cell) biology has expanded
considerably. Key observations have challenged the traditional definition of T reg cells and have …

Experimental autoimmune encephalomyelitis (EAE) is a cell-mediated autoimmune disease
that serves as an animal model for multiple sclerosis. Oral administration of myelin basic …

Thymectomy in mice on neonatal day 3 leads to the development of multiorgan autoimmune
disease due to loss of a CD+ CD25+ T cell regulatory population in their peripheral …

Genome-wide association studies have identified loci underlying human diseases, but the
causal nucleotide changes and mechanisms remain largely unknown. Here we developed a …

… Half the medium was replaced at day 7, and every 3–4 d thereafter it was replaced with fresh
… [H]Thymidine was added to the cultures after 4 d of stimulation. Percent suppression was …

The recent discovery of CD4 + T cells characterized by secretion of interleukin (IL)-17 (T H 17
cells) and the naturally occurring regulatory FOXP3 + CD4 T cell (nT reg ) has had a major …

… d, Cells were stimulated as in a and were rested in the presence of IL-2. After 1 week,
cells were re-stimulated as in a in the presence or absence of NaCl for another week and …

We report the results of a meta-analysis of genome-wide association scans for multiple
sclerosis (MS) susceptibility that includes 2,624 subjects with MS and 7,220 control subjects. …