G-protein-coupled receptors (GPCRs) relay numerous extracellular signals by triggering
intracellular signaling through coupling with G proteins and arrestins. Recent breakthroughs in …

… formed between the side chain of D 2.50 in TM2 and surrounding … of the receptor is the highly
conserved D(E) 3.49 R 3.50 Y … displacement of TM6, which allows the D(E)RY motif to form …

Pulsed electron-electron double resonance techniques such as the four-pulse double
electron-electron resonance experiment measure a dipolar evolution function of the sample. For a …

… In Figure 1D, we represent the two states observed for carazololbound b2AR as two energy
wells of similar depth separated by a shallow energy barrier that allows the fast exchange …

… d, Upon activation, this strand is displaced by the C terminus of V2Rpp, which engages in …
We thank D. Capel for technical assistance and V. Ronk, D. Addison and Q. Lennon for …

This paper provides an overview of the main perspectives and themes emerging in research
on open innovation (OI). The paper is the result of a collaborative process among several OI …

… Titratable residues remained in their dominant protonation state at pH 7, as determined
using PropKa, except for D 2.50 and D 3.49 , which were protonated. Our simulations …

Cannabis elicits its mood-enhancing and analgesic effects through the cannabinoid receptor
1 (CB1), a G protein-coupled receptor (GPCR) that signals primarily through the adenylyl …

… (D) Domain separation is not sufficient for rapid nucleotide release. GDP remains tightly
bound to receptor-free G t (top), even with the helical domain removed (bottom; traces show …

… d, Skeletal structures of ligands used in the current study. e, [ 3 H]DHA competition binding
on unlabelled β 2 ∆6-148C/266C for ligands used in the current study, except for carazolol …